Clinical Spotlight:

74-year-old male with modest improvement in PFTs, able to walk more and sleep better

Patient Profile
Quality of Life Goal	Be able to walk a golf course with multiple stops, take trash to the end of steep driveway without difficulty, sleep better
Condition	Advanced stage Emphysema/COPD (diagnosed at age 58)
Smoking History	Yes, but quit with Dr. Sukkar's help
Management Medications	Breo Singulair ProAir Spiriva Revatio Uroxatral	Lipitor Zithromax Fasenra Hydrodiuril Jardiance Glucophage
Oxygen Use	None
Baseline FEV₁	48% (1390 mL)
Symptoms	Chronic bronchitis Shortness of breath with little exertion Mobility issues

Procedure Details:

Had pulmonary rehab prior to treatment
StratX^®report showed 100% complete fissure on the left side and 56% destruction in the target lobe (Left Lower Lobe)
Collateral ventilation negative by Chartis^®Pulmonary Assessment System
Five Zephyr Valves placed in left lower lobe (LLL)
Three-night hospitalization prior to discharge

Pre and Post-Imaging:

Pre-procedure

Post-procedure

Pre and Post Lung Function Chart:

ASSESSMENT	PRE-PROCEDURE	POST-PROCEDURE (3 MONTHS)
FEV₁	1390 mL	1460 mL
FEV₁ (% pred)	48%	52%
RV	4530 mL	4080 mL
RV (% pred)	172%	156%
TLC	124%	108%
6MWD	527 m	554 m

Case was Completed by:

Dr. Amit ”Bobby” Mahajan at Inova Fairfax Hospital, Fairfax, VA

Patient was Referred by:

Dr. Adlah Sukkar, MD, Pulmonologist

Patient Outcome:

No oxygen use changes
No hospitalizations since treatment
Walking three to five miles a day now and can walk 23-minute mile
Sleeping better

How the Zephyr Valve Works:

The Zephyr Valve is a one-way valve designed to reduce hyperinflation of the lungs caused by severe emphysema/COPD. In a minimally invasive bronchoscopic procedure, an average of four tiny valves are placed in the airways to block off the diseased parts of the lungs where air gets trapped, causing hyperinflation and severe shortness of breath. The Zephyr Valve reduces lung hyperinflation by allowing trapped air to escape and preventing new air from entering that diseased lobe. This allows the healthier parts of the lung to function better and results in patients being able to breathe more easily and experience less shortness of breath.¹

The Zephyr Endobronchial Valve is removable, and thus preserves future therapy options.

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Zephyr Valve Patient Benefits and Risks:

Patients treated report significant improvements in lung function, exercise tolerance, and quality of life.¹

Complications of the Zephyr Endobronchial Valve treatment can include but are not limited to pneumothorax, worsening of COPD symptoms, hemoptysis, pneumonia, dyspnea and, in rare cases, death.

Results from clinical spotlights are not necessarily predictive of results in other cases. Results in other cases may vary.