Interventional Pulmonology - ELVR

Emphysema is a debilitating chronic disease of the lungs

Emphysema is a form of chronic obstructive pulmonary disease (COPD) and is the fourth leading cause of death worldwide.

Air sacs (called alveoli) deteriorate and lose elasticity

  • Oxygen exchange is reduced
  • Air gets trapped in the alveoli, causing the diseased lung region to expand
Healthy alveoli without emphysema

Healthy Lung

Sick alveoli with emphysema

Lung with Emphysema


The diseased region compresses the healthier region, and breathing becomes increasingly more difficult.

Healthy lungs without emphysema

Healthy Lung

Sick lungs with emphysema

Lung with Emphysema

Endobronchial lung volume reduction (LVR) may reduce symptoms associated with emphysema. The Zephyr® Endobronchial Valve is an investigational medical device designed to reduce the volume of the diseased region.

One Zephyr endobronchial valve implanted in the lung
Zephyr valves are placed in the diseased region of the lung.
Three one-way Zephyr endobronchial valve implanted in the lung

The one-way valve prevents airflow into the diseased region during inhalation, while allowing trapped air and fluids to escape upon exhalation.

lung after endobronchial lung volume reduction

Reducing the volume of the diseased region may allow healthier regions to expand and function more efficiently.



Over 12,000 patients worldwide have been treated with the Zephyr® valve, which was approved in Europe in 2003. In this video, European physicians share their experience.

CAUTION: The Zephyr Endobronchial Valve is an investigational device in the US, limited by US law to investigational use.