{"id":91259,"date":"2019-10-18T09:53:05","date_gmt":"2019-10-18T14:53:05","guid":{"rendered":"https:\/\/pulmonx.com\/stelvio-clinical-study\/"},"modified":"2024-08-12T12:31:30","modified_gmt":"2024-08-12T17:31:30","slug":"stelvio-clinical-study","status":"publish","type":"post","link":"https:\/\/pulmonx.com\/uk-en\/stelvio-clinical-study\/","title":{"rendered":"The STELVIO Study"},"content":{"rendered":"\n
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\n \"Zephyr-Valve-Stelvio-Clinical-Study\" \n <\/div>\n \n \n <\/div>\n\n
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Endobronchial-valve treatment in patients with emphysema and a proven absence of interlobar collateral ventilation provided a measurable clinical benefit, with significantly improved lung function, exercise capacity, and quality of life as compared with usual care.\u201d4<\/sup><\/a><\/p>\n

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\n \n Download Study Summary <\/a>\n <\/div>\n <\/div>\n\n <\/div>\n
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Published in The New England Journal of Medicine4<\/sup><\/a><\/h1>\n

The first prospective randomised controlled trial using Chartis\u00ae <\/sup>to select candidates for Zephyr Endobronchial Valve treatment.<\/p>\n

Methods & Endpoints <\/b><\/h3>\n
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  • 68 patients were confirmed with the Chartis System to be collateral ventilation (CV) negative and likely responders to Zephyr\u00ae <\/sup>therapy, and randomised 1:1 to either Zephyr Valve therapy or medical management.<\/li>\n
  • Primary outcome measures were differences between groups for changes in FEV1<\/sub>, FVC, and 6-minute walk distance (6MWD) from baseline to 6 months.<\/li>\n<\/ul> <\/div>\n<\/div>\n <\/div>\n <\/div>\n <\/div>\n
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    Study Design<\/h2> <\/div>\n<\/div>\n\n
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    \n \"STELVIO-Study-Design\" \n <\/div>\n \n \n <\/div>\n\n
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    *The STELVIO trial was performed as an independent physician initiated and conducted trial. Pulmonx was not involved in any part of study.<\/p>\n <\/div>\n<\/div>\n\n

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    Results<\/h2> <\/div>\n<\/div>\n <\/div>\n <\/div>\n
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    Primary Outcome in the Intention-to-Treat Population<\/h4>\n

    Mean change from baseline to 6 months<\/p> <\/div>\n<\/div>\n <\/div>\n

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    FEV1<\/sub><\/h5>\n

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<div data-lazy=\"1\" class=\"module_subrow themify_builder_sub_row tf_w col_align_top tb_col_count_1 tb_0zvg549\">\n <div data-lazy=\"1\" class=\"module_column sub_column col-full tb_9ubz550 first\">\n <!-- module text -->\n<div class=\"module module-text tb_0f2h641 \" data-lazy=\"1\">\n <div class=\"tb_text_wrap\">\n \n<table id=\"tablepress-3\" class=\"tablepress tablepress-id-3 stelvio\">\n<tbody class=\"row-striping\">\n<tr class=\"row-1\">\n\t<td class=\"column-1\"><\/td><td class=\"column-2\">Zephyr Valve Treatment Group<\/td><td class=\"column-3\">SoC<\/td><td class=\"column-4\">\u0394<\/td>\n<\/tr>\n<tr class=\"row-2\">\n\t<td class=\"column-1\">FEV<sub>1<\/sub><\/td><td class=\"column-2\">+20.9%<\/td><td class=\"column-3\">+3.1%<\/td><td class=\"column-4\">+17.8%<\/td>\n<\/tr>\n<tr class=\"row-3\">\n\t<td class=\"column-1\">FVC<\/td><td class=\"column-2\">+18.3%<\/td><td class=\"column-3\">+4.0%<\/td><td class=\"column-4\">+14.4%<\/td>\n<\/tr>\n<tr class=\"row-4\">\n\t<td class=\"column-1\">6MWD<\/td><td class=\"column-2\">+19.6%<\/td><td class=\"column-3\">-3.6%<\/td><td class=\"column-4\">+23.3%<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<!-- #tablepress-3 from cache --> <\/div>\n<\/div>\n<!-- \/module text --> <\/div>\n <\/div>\n <div data-lazy=\"1\" class=\"module_subrow themify_builder_sub_row tf_w col_align_top tb_col_count_1 tb_ugio625\">\n <div data-lazy=\"1\" class=\"module_column sub_column col-full tb_9zfi627 first\">\n <!-- module text -->\n<div class=\"module module-text tb_06vg821 \" data-lazy=\"1\">\n <div class=\"tb_text_wrap\">\n <h3>Clinical Benefits for Both Homogeneous and Heterogeneous Emphysema Subgroups<\/h3>\n<p>Effectiveness outcomes for all Zephyr Valve-treated patients who completed the study. Mean change from baseline.<\/p> <\/div>\n<\/div>\n<!-- \/module text --><!-- module text -->\n<div class=\"module module-text tb_f26i346 hide-tablet hide-mobile\" data-lazy=\"1\">\n <div class=\"tb_text_wrap\">\n \n<table id=\"tablepress-4\" class=\"tablepress tablepress-id-4 stelvio\">\n<tbody class=\"row-striping\">\n<tr class=\"row-1\">\n\t<td class=\"column-1\"><\/td><td class=\"column-2\">Homogeneous Emphysema (n=29)<\/td><td class=\"column-3\">Heterogeneous Emphysema (n=22)<\/td>\n<\/tr>\n<tr class=\"row-2\">\n\t<td class=\"column-1\">FEV<sub>1<\/sub> (%)<\/td><td class=\"column-2\">+20.1<\/td><td class=\"column-3\">+32.6<\/td>\n<\/tr>\n<tr class=\"row-3\">\n\t<td class=\"column-1\">RV (%)<\/td><td class=\"column-2\">-16.3<\/td><td class=\"column-3\">-16.6<\/td>\n<\/tr>\n<tr class=\"row-4\">\n\t<td class=\"column-1\">6MWD (meters)<\/td><td class=\"column-2\">+69<\/td><td class=\"column-3\">+72<\/td>\n<\/tr>\n<tr class=\"row-5\">\n\t<td class=\"column-1\">SGRQ (points)<\/td><td class=\"column-2\">-13<\/td><td class=\"column-3\">-19<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<!-- #tablepress-4 from cache --> <\/div>\n<\/div>\n<!-- \/module text --><!-- module image -->\n<div class=\"module module-image tb_9gtj639 image-center tf_mw hide-desktop hide-tablet_landscape\" data-lazy=\"1\">\n <div class=\"image-wrap tf_rel tf_mw\">\n <img decoding=\"async\" width=\"1196\" height=\"576\" src=\"https:\/\/pulmonx.com\/wp-content\/uploads\/2019\/12\/Zephyr-Heterogenous-Homogenous-STELVIO-Clinical-Study.jpg\" class=\"wp-post-image wp-image-522\" title=\"Zephyr-Heterogenous-Homogenous-STELVIO-Clinical-Study\" alt=\"Zephyr-Heterogenous-Homogenous-STELVIO-Clinical-Study\" srcset=\"https:\/\/pulmonx.com\/wp-content\/uploads\/2019\/12\/Zephyr-Heterogenous-Homogenous-STELVIO-Clinical-Study.jpg 1196w, https:\/\/pulmonx.com\/wp-content\/uploads\/2019\/12\/Zephyr-Heterogenous-Homogenous-STELVIO-Clinical-Study-300x144.jpg 300w, https:\/\/pulmonx.com\/wp-content\/uploads\/2019\/12\/Zephyr-Heterogenous-Homogenous-STELVIO-Clinical-Study-1024x493.jpg 1024w, https:\/\/pulmonx.com\/wp-content\/uploads\/2019\/12\/Zephyr-Heterogenous-Homogenous-STELVIO-Clinical-Study-768x370.jpg 768w\" sizes=\"(max-width: 1196px) 100vw, 1196px\" \/> \n <\/div>\n <!-- \/image-wrap -->\n \n <\/div>\n<!-- \/module image --><!-- module text -->\n<div class=\"module module-text tb_xhsd472 \" data-lazy=\"1\">\n <div class=\"tb_text_wrap\">\n <h3 class=\"p1\">Significantly Greater Responder Rates for Zephyr Valve-treated Patients than Standard of Care<\/h3>\n<p class=\"p2\">MCID responder results among patients who completed the study.<\/p> <\/div>\n<\/div>\n<!-- \/module text --> <\/div>\n <\/div>\n <div data-lazy=\"1\" class=\"module_subrow themify_builder_sub_row tf_w col_align_top tb_col_count_4 tb_ojvn222\">\n <div data-lazy=\"1\" class=\"module_column sub_column col4-1 tb_akwx224 first\">\n <!-- module text -->\n<div class=\"module module-text tb_l2lp137 \" data-lazy=\"1\">\n <div class=\"tb_text_wrap\">\n <p class=\"p1\">Change in FEV<span class=\"s1\"><sub>1 <\/sub><\/span><\/p> <\/div>\n<\/div>\n<!-- \/module text --> <\/div>\n <div data-lazy=\"1\" class=\"module_column sub_column col4-1 tb_gqfc225\">\n <!-- module text -->\n<div class=\"module module-text tb_vi93559 \" data-lazy=\"1\">\n <div class=\"tb_text_wrap\">\n <h5 style=\"text-align: center;\">Control Group<br \/>n=33<\/h5> <\/div>\n<\/div>\n<!-- \/module text --><!-- module plain text -->\n<div class=\"module module-plain-text tb_r15u364 \" data-lazy=\"1\">\n <div class=\"tb_text_wrap\">\n <!DOCTYPE html>\r\n<html>\r\n\t<head>\r\n\t\t<title>STELVIO - FEV1 - Control Group | amCharts<\/title>\r\n\t\t<meta name=\"description\" content=\"chart created using amCharts live editor\" \/>\r\n\t\t\r\n\t\t<!-- amCharts javascript sources -->\r\n\t\t<script type=\"text\/javascript\" 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\"\",\r\n\t\t\t\t\t\t\t\"column-1\": \"60.67\",\r\n\t\t\t\t\t\t\t\"Color\": \"#FF5C39\"\r\n\t\t\t\t\t\t},\r\n\t\t\t\t\t\t{\r\n\t\t\t\t\t\t\t\"category\": \"\",\r\n\t\t\t\t\t\t\t\"column-1\": \"95.24\",\r\n\t\t\t\t\t\t\t\"Color\": \"#FF5C39\"\r\n\t\t\t\t\t\t}\r\n\t\t\t\t\t]\r\n\t\t\t\t}\r\n\t\t\t);\r\n\t\t<\/script>\r\n\t<\/head>\r\n\t<body>\r\n\t\t<div id=\"stelvio-fev1-crossover\" style=\"width: 100%; height: 400px; background-color: #FFFFFF;\" ><\/div>\r\n\t<\/body>\r\n<\/html> <\/div>\n<\/div>\n<!-- \/module plain text --> <\/div>\n <\/div>\n <div data-lazy=\"1\" class=\"module_subrow themify_builder_sub_row tf_w col_align_top tb_col_count_4 tb_3uxs997\">\n <div data-lazy=\"1\" class=\"module_column sub_column col4-1 tb_uy3s998 first\">\n <!-- module text -->\n<div class=\"module module-text tb_7cpn999 \" data-lazy=\"1\">\n <div class=\"tb_text_wrap\">\n <p class=\"p1\">Change in 6MWD<\/p> <\/div>\n<\/div>\n<!-- \/module text --> <\/div>\n <div data-lazy=\"1\" class=\"module_column sub_column col4-1 tb_x11u999\">\n <!-- module text -->\n<div class=\"module module-text tb_2si50 \" data-lazy=\"1\">\n <div class=\"tb_text_wrap\">\n <h5 style=\"text-align: center;\">Control Group<br \/>n=33<\/h5> <\/div>\n<\/div>\n<!-- \/module text --><!-- module plain text -->\n<div class=\"module module-plain-text tb_m63841 \" data-lazy=\"1\">\n <div class=\"tb_text_wrap\">\n <!DOCTYPE html>\r\n<html>\r\n\t<head>\r\n\t\t<title>STELVIO - 6MWD - Control Group | amCharts<\/title>\r\n\t\t<meta name=\"description\" content=\"chart created using amCharts live editor\" \/>\r\n\t\t\r\n\t\t<!-- amCharts javascript sources -->\r\n\t\t<script type=\"text\/javascript\" src=\"https:\/\/www.amcharts.com\/lib\/3\/amcharts.js\"><\/script>\r\n\t\t<script type=\"text\/javascript\" src=\"https:\/\/cdn.amcharts.com\/lib\/3\/serial.js\"><\/script>\r\n\t\t<script type=\"text\/javascript\" src=\"https:\/\/www.amcharts.com\/lib\/3\/themes\/light.js\"><\/script>\r\n\t\t\r\n\r\n\t\t<!-- amCharts javascript 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><\/div>\r\n\t<\/body>\r\n<\/html> <\/div>\n<\/div>\n<!-- \/module plain text --> <\/div>\n <div data-lazy=\"1\" class=\"module_column sub_column col4-1 tb_xfsv0\">\n <!-- module text -->\n<div class=\"module module-text tb_kedb0 \" data-lazy=\"1\">\n <div class=\"tb_text_wrap\">\n <h5 style=\"text-align: center;\">Zephyr Valve Group<br \/>n=25<\/h5> <\/div>\n<\/div>\n<!-- \/module text --><!-- module plain text -->\n<div class=\"module module-plain-text tb_s7o4650 \" data-lazy=\"1\">\n <div class=\"tb_text_wrap\">\n <!DOCTYPE html>\r\n<html>\r\n\t<head>\r\n\t\t<title>STELVIO - 6MWD - Zephyr Valve | amCharts<\/title>\r\n\t\t<meta name=\"description\" content=\"chart created using amCharts live editor\" \/>\r\n\t\t\r\n\t\t<!-- amCharts javascript sources -->\r\n\t\t<script type=\"text\/javascript\" src=\"https:\/\/www.amcharts.com\/lib\/3\/amcharts.js\"><\/script>\r\n\t\t<script type=\"text\/javascript\" src=\"https:\/\/cdn.amcharts.com\/lib\/3\/serial.js\"><\/script>\r\n\t\t<script 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\"#FF5C39\"\r\n\t\t\t\t\t\t},\r\n\t\t\t\t\t\t{\r\n\t\t\t\t\t\t\t\"category\": null,\r\n\t\t\t\t\t\t\t\"column-1\": \"112\",\r\n\t\t\t\t\t\t\t\"Color\": \"#FF5C39\"\r\n\t\t\t\t\t\t},\r\n\t\t\t\t\t\t{\r\n\t\t\t\t\t\t\t\"category\": \"\",\r\n\t\t\t\t\t\t\t\"column-1\": \"114\",\r\n\t\t\t\t\t\t\t\"Color\": \"#FF5C39\"\r\n\t\t\t\t\t\t}\r\n\t\t\t\t\t]\r\n\t\t\t\t}\r\n\t\t\t);\r\n\t\t<\/script>\r\n\t<\/head>\r\n\t<body>\r\n\t\t<div id=\"stelvio-6mwd-crossover\" style=\"width: 100%; height: 400px; background-color: #FFFFFF;\" ><\/div>\r\n\t<\/body>\r\n<\/html> <\/div>\n<\/div>\n<!-- \/module plain text --> <\/div>\n <\/div>\n <div data-lazy=\"1\" class=\"module_subrow themify_builder_sub_row tf_w col_align_top tb_col_count_4 tb_4t40589\">\n <div data-lazy=\"1\" class=\"module_column sub_column col4-1 tb_ouuy589 first\">\n <!-- module text -->\n<div class=\"module module-text tb_n5mf334 \" data-lazy=\"1\">\n <div class=\"tb_text_wrap\">\n <p class=\"p1\">Change in SGRQ<\/p> <\/div>\n<\/div>\n<!-- \/module text --> <\/div>\n <div data-lazy=\"1\" class=\"module_column sub_column col4-1 tb_ye4z590\">\n <!-- module text -->\n<div class=\"module module-text tb_jufa590 \" data-lazy=\"1\">\n <div class=\"tb_text_wrap\">\n <h5 style=\"text-align: center;\">Control Group<br \/>n=33<\/h5> <\/div>\n<\/div>\n<!-- \/module text --><!-- module plain text -->\n<div class=\"module module-plain-text tb_bgw7256 \" data-lazy=\"1\">\n <div class=\"tb_text_wrap\">\n <!DOCTYPE html>\r\n<html>\r\n\t<head>\r\n\t\t<title>STELVIO - SGRQ - Control Group | amCharts<\/title>\r\n\t\t<meta name=\"description\" content=\"chart created using amCharts live editor\" \/>\r\n\t\t\r\n\t\t<!-- amCharts javascript sources -->\r\n\t\t<script type=\"text\/javascript\" src=\"https:\/\/www.amcharts.com\/lib\/3\/amcharts.js\"><\/script>\r\n\t\t<script type=\"text\/javascript\" src=\"https:\/\/cdn.amcharts.com\/lib\/3\/serial.js\"><\/script>\r\n\t\t<script type=\"text\/javascript\" src=\"https:\/\/www.amcharts.com\/lib\/3\/themes\/light.js\"><\/script>\r\n\t\t\r\n\r\n\t\t<!-- amCharts javascript code -->\r\n\t\t<script type=\"text\/javascript\">\r\n\t\t\tAmCharts.makeChart(\"stelvio-sgrq-control-group\",\r\n\t\t\t\t{\r\n \"hideCredits\": \"true\",\r\n\t\t\t\t\t\"type\": \"serial\",\r\n\t\t\t\t\t\"categoryField\": \"category\",\r\n\t\t\t\t\t\"autoMarginOffset\": 0,\r\n\t\t\t\t\t\"autoMargins\": false,\r\n\t\t\t\t\t\"marginBottom\": 60,\r\n\t\t\t\t\t\"marginLeft\": 68,\r\n\t\t\t\t\t\"marginRight\": 95,\r\n\t\t\t\t\t\"marginTop\": 55,\r\n\t\t\t\t\t\"plotAreaFillColors\": \"\",\r\n\t\t\t\t\t\"startDuration\": 2,\r\n\t\t\t\t\t\"startEffect\": \"easeOutSine\",\r\n\t\t\t\t\t\"accessibleTitle\": \"liberatepercentofsubjectsfev\",\r\n\t\t\t\t\t\"backgroundAlpha\": 0.8,\r\n\t\t\t\t\t\"borderColor\": \"\",\r\n\t\t\t\t\t\"fontFamily\": \"Arial\",\r\n\t\t\t\t\t\"fontSize\": 14,\r\n\t\t\t\t\t\"pathToImages\": \"http:\/\/cdn.amcharts.com\/lib\/3\/images\/\",\r\n\t\t\t\t\t\"theme\": \"light\",\r\n\t\t\t\t\t\"categoryAxis\": {\r\n\t\t\t\t\t\t\"classNameField\": \"\",\r\n\t\t\t\t\t\t\"gridPosition\": \"start\",\r\n\t\t\t\t\t\t\"axisThickness\": 0,\r\n\t\t\t\t\t\t\"boldLabels\": true,\r\n\t\t\t\t\t\t\"centerLabels\": true,\r\n\t\t\t\t\t\t\"fontSize\": 14,\r\n\t\t\t\t\t\t\"gridColor\": \"#FFFFFF\",\r\n\t\t\t\t\t\t\"tickLength\": 0,\r\n\t\t\t\t\t\t\"title\": \"\"\r\n\t\t\t\t\t},\r\n\t\t\t\t\t\"trendLines\": [],\r\n\t\t\t\t\t\"graphs\": [\r\n\t\t\t\t\t\t{\r\n\t\t\t\t\t\t\t\"accessibleLabel\": \"STELVIO - SGRQ - Control Group - MCID Responder Rates\",\r\n\t\t\t\t\t\t\t\"balloonText\": \"\",\r\n\t\t\t\t\t\t\t\"colorField\": \"Color\",\r\n\t\t\t\t\t\t\t\"customMarker\": \"\",\r\n\t\t\t\t\t\t\t\"fillAlphas\": 1,\r\n\t\t\t\t\t\t\t\"id\": \"AmGraph-1\",\r\n\t\t\t\t\t\t\t\"labelText\": \"\",\r\n\t\t\t\t\t\t\t\"legendColor\": \"#3095B4\",\r\n\t\t\t\t\t\t\t\"legendPeriodValueText\": \"\",\r\n\t\t\t\t\t\t\t\"lineColor\": \"\",\r\n\t\t\t\t\t\t\t\"lineThickness\": 0,\r\n\t\t\t\t\t\t\t\"negativeFillAlphas\": 0,\r\n\t\t\t\t\t\t\t\"negativeFillColors\": \"\",\r\n\t\t\t\t\t\t\t\"negativeLineAlpha\": 0,\r\n\t\t\t\t\t\t\t\"showBalloon\": false,\r\n\t\t\t\t\t\t\t\"switchable\": false,\r\n\t\t\t\t\t\t\t\"title\": \"Responders\",\r\n\t\t\t\t\t\t\t\"type\": \"column\",\r\n\t\t\t\t\t\t\t\"valueField\": \"column-1\"\r\n\t\t\t\t\t\t},\r\n\t\t\t\t\t\t{\r\n\t\t\t\t\t\t\t\"accessibleLabel\": \"STELVIO - SGRQ - Control Group - MCID Responder Rates\",\r\n\t\t\t\t\t\t\t\"balloonText\": \"\",\r\n\t\t\t\t\t\t\t\"id\": \"AmGraph-2\",\r\n\t\t\t\t\t\t\t\"legendColor\": \"#AAB3B3\",\r\n\t\t\t\t\t\t\t\"title\": \"Non-responders\"\r\n\t\t\t\t\t\t}\r\n\t\t\t\t\t],\r\n\t\t\t\t\t\"guides\": [\r\n\t\t\t\t\t\t{\r\n\t\t\t\t\t\t\t\"above\": true,\r\n\t\t\t\t\t\t\t\"id\": \"Guide-1\",\r\n\t\t\t\t\t\t\t\"inside\": false,\r\n\t\t\t\t\t\t\t\"label\": \"MCID (-4 pts)\",\r\n\t\t\t\t\t\t\t\"lineThickness\": 3,\r\n\t\t\t\t\t\t\t\"position\": \"right\",\r\n\t\t\t\t\t\t\t\"value\": -4\r\n\t\t\t\t\t\t}\r\n\t\t\t\t\t],\r\n\t\t\t\t\t\"valueAxes\": [\r\n\t\t\t\t\t\t{\r\n\t\t\t\t\t\t\t\"id\": \"ValueAxis-1\",\r\n\t\t\t\t\t\t\t\"maximum\": 20,\r\n\t\t\t\t\t\t\t\"minimum\": -60,\r\n\t\t\t\t\t\t\t\"treatZeroAs\": 20,\r\n\t\t\t\t\t\t\t\"autoGridCount\": false,\r\n\t\t\t\t\t\t\t\"gridCount\": 10,\r\n\t\t\t\t\t\t\t\"title\": \"Points (pts)\"\r\n\t\t\t\t\t\t}\r\n\t\t\t\t\t],\r\n\t\t\t\t\t\"allLabels\": [],\r\n\t\t\t\t\t\"balloon\": {\r\n\t\t\t\t\t\t\"borderThickness\": 1\r\n\t\t\t\t\t},\r\n\t\t\t\t\t\"legend\": {\r\n\t\t\t\t\t\t\"enabled\": true,\r\n\t\t\t\t\t\t\"combineLegend\": true,\r\n\t\t\t\t\t\t\"switchable\": false\r\n\t\t\t\t\t},\r\n\t\t\t\t\t\"titles\": [],\r\n\t\t\t\t\t\"dataProvider\": [\r\n\t\t\t\t\t\t{\r\n\t\t\t\t\t\t\t\"category\": \"\",\r\n\t\t\t\t\t\t\t\"column-1\": \"9.07\",\r\n\t\t\t\t\t\t\t\"Color\": \"#97999B\"\r\n\t\t\t\t\t\t},\r\n\t\t\t\t\t\t{\r\n\t\t\t\t\t\t\t\"category\": \"\",\r\n\t\t\t\t\t\t\t\"column-1\": \"8.74\",\r\n\t\t\t\t\t\t\t\"Color\": \"#97999B\"\r\n\t\t\t\t\t\t},\r\n\t\t\t\t\t\t{\r\n\t\t\t\t\t\t\t\"category\": \"\",\r\n\t\t\t\t\t\t\t\"column-1\": \"8.2\",\r\n\t\t\t\t\t\t\t\"Color\": \"#97999B\"\r\n\t\t\t\t\t\t},\r\n\t\t\t\t\t\t{\r\n\t\t\t\t\t\t\t\"category\": \"\",\r\n\t\t\t\t\t\t\t\"column-1\": \"8.15\",\r\n\t\t\t\t\t\t\t\"Color\": \"#97999B\"\r\n\t\t\t\t\t\t},\r\n\t\t\t\t\t\t{\r\n\t\t\t\t\t\t\t\"category\": \"\",\r\n\t\t\t\t\t\t\t\"column-1\": \"7.87\",\r\n\t\t\t\t\t\t\t\"Color\": \"#97999B\"\r\n\t\t\t\t\t\t},\r\n\t\t\t\t\t\t{\r\n\t\t\t\t\t\t\t\"category\": \"\",\r\n\t\t\t\t\t\t\t\"column-1\": \"7.39\",\r\n\t\t\t\t\t\t\t\"Color\": \"#97999B\"\r\n\t\t\t\t\t\t},\r\n\t\t\t\t\t\t{\r\n\t\t\t\t\t\t\t\"category\": \"\",\r\n\t\t\t\t\t\t\t\"column-1\": \"7.3\",\r\n\t\t\t\t\t\t\t\"Color\": \"#97999B\"\r\n\t\t\t\t\t\t},\r\n\t\t\t\t\t\t{\r\n\t\t\t\t\t\t\t\"category\": \"\",\r\n\t\t\t\t\t\t\t\"column-1\": \"3.92\",\r\n\t\t\t\t\t\t\t\"Color\": \"#97999B\"\r\n\t\t\t\t\t\t},\r\n\t\t\t\t\t\t{\r\n\t\t\t\t\t\t\t\"category\": \"\",\r\n\t\t\t\t\t\t\t\"column-1\": \"2.09\",\r\n\t\t\t\t\t\t\t\"Color\": \"#97999B\"\r\n\t\t\t\t\t\t},\r\n\t\t\t\t\t\t{\r\n\t\t\t\t\t\t\t\"category\": \"\",\r\n\t\t\t\t\t\t\t\"column-1\": \"1.85\",\r\n\t\t\t\t\t\t\t\"Color\": \"#97999B\"\r\n\t\t\t\t\t\t},\r\n\t\t\t\t\t\t{\r\n\t\t\t\t\t\t\t\"category\": \"\",\r\n\t\t\t\t\t\t\t\"column-1\": \"1.61\",\r\n\t\t\t\t\t\t\t\"Color\": \"#97999B\"\r\n\t\t\t\t\t\t},\r\n\t\t\t\t\t\t{\r\n\t\t\t\t\t\t\t\"category\": \"\",\r\n\t\t\t\t\t\t\t\"column-1\": \".84\",\r\n\t\t\t\t\t\t\t\"Color\": \"#97999B\"\r\n\t\t\t\t\t\t},\r\n\t\t\t\t\t\t{\r\n\t\t\t\t\t\t\t\"category\": \"\",\r\n\t\t\t\t\t\t\t\"column-1\": \"-.09\",\r\n\t\t\t\t\t\t\t\"Color\": \"#97999B\"\r\n\t\t\t\t\t\t},\r\n\t\t\t\t\t\t{\r\n\t\t\t\t\t\t\t\"category\": \"\",\r\n\t\t\t\t\t\t\t\"column-1\": \"-.45\",\r\n\t\t\t\t\t\t\t\"Color\": \"#97999B\"\r\n\t\t\t\t\t\t},\r\n\t\t\t\t\t\t{\r\n\t\t\t\t\t\t\t\"category\": \"\",\r\n\t\t\t\t\t\t\t\"column-1\": \"-.47\",\r\n\t\t\t\t\t\t\t\"Color\": \"#97999B\"\r\n\t\t\t\t\t\t},\r\n\t\t\t\t\t\t{\r\n\t\t\t\t\t\t\t\"category\": \"\",\r\n\t\t\t\t\t\t\t\"column-1\": \"-.98\",\r\n\t\t\t\t\t\t\t\"Color\": \"#97999B\"\r\n\t\t\t\t\t\t},\r\n\t\t\t\t\t\t{\r\n\t\t\t\t\t\t\t\"category\": \"\",\r\n\t\t\t\t\t\t\t\"column-1\": \"-1.02\",\r\n\t\t\t\t\t\t\t\"Color\": \"#97999B\"\r\n\t\t\t\t\t\t},\r\n\t\t\t\t\t\t{\r\n\t\t\t\t\t\t\t\"category\": \"\",\r\n\t\t\t\t\t\t\t\"column-1\": \"-1.77\",\r\n\t\t\t\t\t\t\t\"Color\": \"#97999B\"\r\n\t\t\t\t\t\t},\r\n\t\t\t\t\t\t{\r\n\t\t\t\t\t\t\t\"category\": \"\",\r\n\t\t\t\t\t\t\t\"column-1\": \"-1.98\",\r\n\t\t\t\t\t\t\t\"Color\": \"#97999B\"\r\n\t\t\t\t\t\t},\r\n\t\t\t\t\t\t{\r\n\t\t\t\t\t\t\t\"category\": \"\",\r\n\t\t\t\t\t\t\t\"column-1\": \"-2.52\",\r\n\t\t\t\t\t\t\t\"Color\": \"#97999B\"\r\n\t\t\t\t\t\t},\r\n\t\t\t\t\t\t{\r\n\t\t\t\t\t\t\t\"category\": \"\",\r\n\t\t\t\t\t\t\t\"column-1\": \"-2.76\",\r\n\t\t\t\t\t\t\t\"Color\": \"#97999B\"\r\n\t\t\t\t\t\t},\r\n\t\t\t\t\t\t{\r\n\t\t\t\t\t\t\t\"category\": \"\",\r\n\t\t\t\t\t\t\t\"column-1\": \"-2.89\",\r\n\t\t\t\t\t\t\t\"Color\": \"#97999B\"\r\n\t\t\t\t\t\t},\r\n\t\t\t\t\t\t{\r\n\t\t\t\t\t\t\t\"category\": \"\",\r\n\t\t\t\t\t\t\t\"column-1\": \"-8.83\",\r\n\t\t\t\t\t\t\t\"Color\": \"#3095B4\"\r\n\t\t\t\t\t\t},\r\n\t\t\t\t\t\t{\r\n\t\t\t\t\t\t\t\"category\": \"\",\r\n\t\t\t\t\t\t\t\"column-1\": \"-8.9\",\r\n\t\t\t\t\t\t\t\"Color\": \"#3095B4\"\r\n\t\t\t\t\t\t},\r\n\t\t\t\t\t\t{\r\n\t\t\t\t\t\t\t\"category\": \"\",\r\n\t\t\t\t\t\t\t\"column-1\": \"-10.34\",\r\n\t\t\t\t\t\t\t\"Color\": \"#3095B4\"\r\n\t\t\t\t\t\t},\r\n\t\t\t\t\t\t{\r\n\t\t\t\t\t\t\t\"category\": \"\",\r\n\t\t\t\t\t\t\t\"column-1\": \"-10.48\",\r\n\t\t\t\t\t\t\t\"Color\": \"#3095B4\"\r\n\t\t\t\t\t\t},\r\n\t\t\t\t\t\t{\r\n\t\t\t\t\t\t\t\"category\": \"\",\r\n\t\t\t\t\t\t\t\"column-1\": \"-15.35\",\r\n\t\t\t\t\t\t\t\"Color\": \"#3095B4\"\r\n\t\t\t\t\t\t},\r\n\t\t\t\t\t\t{\r\n\t\t\t\t\t\t\t\"category\": \"\",\r\n\t\t\t\t\t\t\t\"column-1\": \"-17.87\",\r\n\t\t\t\t\t\t\t\"Color\": \"#3095B4\"\r\n\t\t\t\t\t\t},\r\n\t\t\t\t\t\t{\r\n\t\t\t\t\t\t\t\"category\": \"\",\r\n\t\t\t\t\t\t\t\"column-1\": \"-23.82\",\r\n\t\t\t\t\t\t\t\"Color\": \"#3095B4\"\r\n\t\t\t\t\t\t},\r\n\t\t\t\t\t\t{\r\n\t\t\t\t\t\t\t\"category\": \"\",\r\n\t\t\t\t\t\t\t\"column-1\": \"-25.26\",\r\n\t\t\t\t\t\t\t\"Color\": \"#3095B4\"\r\n\t\t\t\t\t\t}\r\n\t\t\t\t\t]\r\n\t\t\t\t}\r\n\t\t\t);\r\n\t\t<\/script>\r\n\t<\/head>\r\n\t<body>\r\n\t\t<div id=\"stelvio-sgrq-control-group\" style=\"width: 100%; height: 400px; background-color: #FFFFFF;\" ><\/div>\r\n\t<\/body>\r\n<\/html> <\/div>\n<\/div>\n<!-- \/module plain text --> <\/div>\n <div data-lazy=\"1\" class=\"module_column sub_column col4-1 tb_5re9590\">\n <!-- module text -->\n<div class=\"module module-text tb_86n1590 \" data-lazy=\"1\">\n <div class=\"tb_text_wrap\">\n <h5 style=\"text-align: center;\">Zephyr Valve Group<br \/>n=25<\/h5> <\/div>\n<\/div>\n<!-- \/module text --><!-- module plain text -->\n<div class=\"module module-plain-text tb_0oto749 \" data-lazy=\"1\">\n <div class=\"tb_text_wrap\">\n <!DOCTYPE html>\r\n<html>\r\n\t<head>\r\n\t\t<title>STELVIO - SGRQ - Zephyr Valve | amCharts<\/title>\r\n\t\t<meta name=\"description\" content=\"chart created using amCharts live editor\" \/>\r\n\t\t\r\n\t\t<!-- amCharts javascript sources -->\r\n\t\t<script type=\"text\/javascript\" src=\"https:\/\/www.amcharts.com\/lib\/3\/amcharts.js\"><\/script>\r\n\t\t<script type=\"text\/javascript\" src=\"https:\/\/cdn.amcharts.com\/lib\/3\/serial.js\"><\/script>\r\n\t\t<script type=\"text\/javascript\" src=\"https:\/\/www.amcharts.com\/lib\/3\/themes\/light.js\"><\/script>\r\n\t\t\r\n\r\n\t\t<!-- amCharts javascript code -->\r\n\t\t<script type=\"text\/javascript\">\r\n\t\t\tAmCharts.makeChart(\"stelvio-sgrq-ebv\",\r\n\t\t\t\t{\r\n \"hideCredits\": \"true\",\r\n\t\t\t\t\t\"type\": \"serial\",\r\n\t\t\t\t\t\"categoryField\": \"category\",\r\n\t\t\t\t\t\"autoMarginOffset\": 0,\r\n\t\t\t\t\t\"autoMargins\": false,\r\n\t\t\t\t\t\"marginBottom\": 60,\r\n\t\t\t\t\t\"marginLeft\": 68,\r\n\t\t\t\t\t\"marginRight\": 95,\r\n\t\t\t\t\t\"marginTop\": 55,\r\n\t\t\t\t\t\"plotAreaFillColors\": \"\",\r\n\t\t\t\t\t\"startDuration\": 2,\r\n\t\t\t\t\t\"startEffect\": \"easeOutSine\",\r\n\t\t\t\t\t\"accessibleTitle\": \"liberatepercentofsubjectsfev\",\r\n\t\t\t\t\t\"backgroundAlpha\": 0.8,\r\n\t\t\t\t\t\"borderColor\": \"\",\r\n\t\t\t\t\t\"fontFamily\": \"Arial\",\r\n\t\t\t\t\t\"fontSize\": 14,\r\n\t\t\t\t\t\"pathToImages\": \"http:\/\/cdn.amcharts.com\/lib\/3\/images\/\",\r\n\t\t\t\t\t\"theme\": \"light\",\r\n\t\t\t\t\t\"categoryAxis\": {\r\n\t\t\t\t\t\t\"classNameField\": \"\",\r\n\t\t\t\t\t\t\"gridPosition\": \"start\",\r\n\t\t\t\t\t\t\"axisThickness\": 0,\r\n\t\t\t\t\t\t\"boldLabels\": true,\r\n\t\t\t\t\t\t\"centerLabels\": true,\r\n\t\t\t\t\t\t\"fontSize\": 14,\r\n\t\t\t\t\t\t\"gridColor\": \"#FFFFFF\",\r\n\t\t\t\t\t\t\"tickLength\": 0,\r\n\t\t\t\t\t\t\"title\": \"\"\r\n\t\t\t\t\t},\r\n\t\t\t\t\t\"trendLines\": [],\r\n\t\t\t\t\t\"graphs\": [\r\n\t\t\t\t\t\t{\r\n\t\t\t\t\t\t\t\"accessibleLabel\": \"STELVIO - SGRQ - Zephyr Valve Group - MCID Responder Rates\",\r\n\t\t\t\t\t\t\t\"balloonText\": \"\",\r\n\t\t\t\t\t\t\t\"colorField\": \"Color\",\r\n\t\t\t\t\t\t\t\"customMarker\": \"\",\r\n\t\t\t\t\t\t\t\"fillAlphas\": 1,\r\n\t\t\t\t\t\t\t\"id\": \"AmGraph-1\",\r\n\t\t\t\t\t\t\t\"labelText\": \"\",\r\n\t\t\t\t\t\t\t\"legendColor\": \"#4F2D7F\",\r\n\t\t\t\t\t\t\t\"legendPeriodValueText\": \"\",\r\n\t\t\t\t\t\t\t\"lineColor\": \"\",\r\n\t\t\t\t\t\t\t\"lineThickness\": 0,\r\n\t\t\t\t\t\t\t\"negativeFillAlphas\": 0,\r\n\t\t\t\t\t\t\t\"negativeFillColors\": \"\",\r\n\t\t\t\t\t\t\t\"negativeLineAlpha\": 0,\r\n\t\t\t\t\t\t\t\"showBalloon\": false,\r\n\t\t\t\t\t\t\t\"switchable\": false,\r\n\t\t\t\t\t\t\t\"title\": 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\"#4F2D7F\"\r\n\t\t\t\t\t\t},\r\n\t\t\t\t\t\t{\r\n\t\t\t\t\t\t\t\"category\": \"\",\r\n\t\t\t\t\t\t\t\"column-1\": \"-49.67\",\r\n\t\t\t\t\t\t\t\"Color\": \"#4F2D7F\"\r\n\t\t\t\t\t\t},\r\n\t\t\t\t\t\t{\r\n\t\t\t\t\t\t\t\"category\": \"\",\r\n\t\t\t\t\t\t\t\"column-1\": \"-53.16\",\r\n\t\t\t\t\t\t\t\"Color\": \"#4F2D7F\"\r\n\t\t\t\t\t\t}\r\n\t\t\t\t\t]\r\n\t\t\t\t}\r\n\t\t\t);\r\n\t\t<\/script>\r\n\t<\/head>\r\n\t<body>\r\n\t\t<div id=\"stelvio-sgrq-ebv\" style=\"width: 100%; height: 400px; background-color: #FFFFFF;\" ><\/div>\r\n\t<\/body>\r\n<\/html> <\/div>\n<\/div>\n<!-- \/module plain text --> <\/div>\n <div data-lazy=\"1\" class=\"module_column sub_column col4-1 tb_sty1592 last\">\n <!-- module text -->\n<div class=\"module module-text tb_pqjj592 \" data-lazy=\"1\">\n <div class=\"tb_text_wrap\">\n <h5 style=\"text-align: center;\">Crossover Zephyr Valve Group<br \/>n=26<\/h5> <\/div>\n<\/div>\n<!-- \/module text --><!-- module plain text -->\n<div class=\"module 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40px;\" data-lazy=\"1\">\n <\/div>\n<!-- \/module divider -->\n<!-- module text -->\n<div class=\"module module-text tb_u6r8619 \" data-lazy=\"1\">\n <div class=\"tb_text_wrap\">\n <h2 class=\"p1\">Conclusion<\/h2>\n<p class=\"p1\">Endobronchial valve treatment significantly improved pulmonary function and exercise capacity in patients with severe emphysema characterized by an absence of interlobar collateral ventilation.<\/p>\n<p>Complications of the Zephyr Endobronchial Valve treatment can include but are not limited to pneumothorax, worsening of COPD symptoms, hemoptysis, pneumonia, dyspnea and, in rare cases, death.<\/p> <\/div>\n<\/div>\n<!-- \/module text --> <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n<!--\/themify_builder_content-->","protected":false},"excerpt":{"rendered":"<p>A multicenter, multinational randomized controlled trial of Zephyr\u00ae Endobronchial Valves in patients with heterogenous emphysema and little to no collateral ventilation.<\/p>\n","protected":false},"author":2,"featured_media":91261,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[192],"tags":[],"class_list":["post-91259","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-clinical-studies-uk-en","has-post-title","has-post-date","has-post-category","has-post-tag","has-post-comment","has-post-author",""],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>STELVIO Clinical Study \u2014 First Trial Using Chartis | Pulmonx<\/title>\n<meta name=\"description\" content=\"The STELVIO clinical study was the first prospective randomized controlled trial using Chartis\u00ae to select candidates for Zephyr treatment.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, 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