{"id":91255,"date":"2019-10-18T09:38:11","date_gmt":"2019-10-18T14:38:11","guid":{"rendered":"https:\/\/pulmonx.com\/impact-clinical-study\/"},"modified":"2024-08-12T12:30:37","modified_gmt":"2024-08-12T17:30:37","slug":"impact-clinical-study","status":"publish","type":"post","link":"https:\/\/pulmonx.com\/uk-en\/impact-clinical-study\/","title":{"rendered":"The IMPACT Study"},"content":{"rendered":"\n
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\n \"Zephyr-Valve-Impact-Clinical-Study\" \n <\/div>\n \n \n <\/div>\n\n
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EBV therapy in selected patients with homogeneous emphysema without collateral ventilation results in clinically meaningful benefits of improved lung function, exercise tolerance, and quality of life. Given the very limited treatment options available for this patient population, EBV therapy should be considered in these patients.\u201d3<\/sup><\/a><\/p>\n<\/blockquote> <\/div>\n<\/div>\n\n

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\n \n Download Study Summary <\/a>\n <\/div>\n <\/div>\n\n <\/div>\n
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Published in The American Journal of Respiratory and Critical Care Medicine3<\/sup><\/a><\/h1>\n

The first prospective randomised controlled trial of Zephyr\u00ae<\/sup> Endobronchial Valves specifically in patients with homogeneous emphysema and little to no collateral ventilation (CV).<\/p>\n

Methods<\/h3>\n
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    93 patients with homogeneous emphysema were confirmed with the Chartis\u00ae<\/sup> <\/span>System to be CV negative and likely responders to Zephyr Valve treatment and randomised 1:1 to either Zephyr Valve treatment or medical management.<\/p>\n<\/li>\n

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    For Zephyr Valve-treated patients, target lobes were selected based on emphysema destruction scores and regional perfusion impairments and were then completely occluded with valves.<\/p>\n<\/li>\n

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    If patients did not feel a benefit, the valve position was assessed at 30 days by CT and removed and replaced if necessary.<\/p>\n<\/li>\n<\/ul> <\/div>\n<\/div>\n <\/div>\n <\/div>\n <\/div>\n

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    Study Design<\/h2> <\/div>\n<\/div>\n\n
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    \n \"IMPACT-Study-Design\" \n <\/div>\n \n \n <\/div>\n\n
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    Results<\/h2> <\/div>\n<\/div>\n
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    Primary Outcome in the Intention-to-Treat Population<\/h4>\n

    FEV1<\/sub> Percent change from baseline to 3 months<\/p>\n

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background-color: #FFFFFF;\" ><\/div>\r\n\t<\/body>\r\n<\/html><\/p> <\/div>\n<\/div>\n<!-- \/module text --> <\/div>\n <div data-lazy=\"1\" class=\"module_column sub_column col4-1 tb_xum359 last\">\n <\/div>\n <\/div>\n <div data-lazy=\"1\" class=\"module_subrow themify_builder_sub_row tf_w col_align_top tb_col_count_1 tb_ugio625\">\n <div data-lazy=\"1\" class=\"module_column sub_column col-full tb_9zfi627 first\">\n <!-- module text -->\n<div class=\"module module-text tb_06vg821 \" data-lazy=\"1\">\n <div class=\"tb_text_wrap\">\n <h3>Secondary Endpoints in the Intention-to-Treat Population<\/h3>\n<h5 class=\"p1\">Zephyr Valve n=43, Control Group n=50<\/h5> <\/div>\n<\/div>\n<!-- \/module text --> <\/div>\n <\/div>\n <div data-lazy=\"1\" class=\"module_subrow themify_builder_sub_row tf_w col_align_top tb_col_count_3 tb_ojvn222\">\n <div data-lazy=\"1\" class=\"module_column sub_column col3-1 tb_akwx224 first\">\n <!-- module text -->\n<div class=\"module module-text tb_vi93559 \" 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Difference\",\r\n\t\t\t\t\t\t\t\"valueField\": \"Between Group Difference\"\r\n\t\t\t\t\t\t}\r\n\t\t\t\t\t],\r\n\t\t\t\t\t\"guides\": [],\r\n\t\t\t\t\t\"valueAxes\": [\r\n\t\t\t\t\t\t{\r\n\t\t\t\t\t\t\t\"axisFrequency\": 2,\r\n\t\t\t\t\t\t\t\"id\": \"ValueAxis-1\",\r\n\t\t\t\t\t\t\t\"maximum\": 50,\r\n\t\t\t\t\t\t\t\"minimum\": -30,\r\n\t\t\t\t\t\t\t\"minMaxMultiplier\": 6,\r\n\t\t\t\t\t\t\t\"unit\": \"\",\r\n\t\t\t\t\t\t\t\"autoGridCount\": false,\r\n\t\t\t\t\t\t\t\"gridCount\": 8,\r\n\t\t\t\t\t\t\t\"minVerticalGap\": 39,\r\n\t\t\t\t\t\t\t\"title\": \"Meters (m)\"\r\n\t\t\t\t\t\t}\r\n\t\t\t\t\t],\r\n\t\t\t\t\t\"allLabels\": [\r\n\t\t\t\t\t\t{\r\n\t\t\t\t\t\t\t\"id\": \"Label-1\",\r\n\t\t\t\t\t\t\t\"text\": \"p=0.016\",\r\n\t\t\t\t\t\t\t\"x\": \"76%\",\r\n\t\t\t\t\t\t\t\"y\": \"30%\"\r\n\t\t\t\t\t\t},\r\n\t\t\t\t\t\t{\r\n\t\t\t\t\t\t\t\"id\": \"Label-2\",\r\n\t\t\t\t\t\t\t\"text\": \"p=0.002\",\r\n\t\t\t\t\t\t\t\"x\": \"50%\",\r\n\t\t\t\t\t\t\t\"y\": \"23%\"\r\n\t\t\t\t\t\t}\r\n\t\t\t\t\t],\r\n\t\t\t\t\t\"balloon\": {\r\n\t\t\t\t\t\t\"borderThickness\": 1\r\n\t\t\t\t\t},\r\n\t\t\t\t\t\"legend\": {\r\n\t\t\t\t\t\t\"enabled\": true,\r\n\t\t\t\t\t\t\"switchable\": false,\r\n\t\t\t\t\t\t\"tabIndex\": 8,\r\n\t\t\t\t\t\t\"valueAlign\": \"left\"\r\n\t\t\t\t\t},\r\n\t\t\t\t\t\"titles\": [],\r\n\t\t\t\t\t\"dataProvider\": [\r\n\t\t\t\t\t\t{\r\n\t\t\t\t\t\t\t\"category\": \"Baseline\",\r\n\t\t\t\t\t\t\t\"EBV\": \"0\",\r\n\t\t\t\t\t\t\t\"Control\": \"0\",\r\n\t\t\t\t\t\t\t\"EBV Candle High\": \"0\",\r\n\t\t\t\t\t\t\t\"EBVCandle Low\": \"0\",\r\n\t\t\t\t\t\t\t\"EBV open\": \"0\",\r\n\t\t\t\t\t\t\t\"EBV close\": \"0\",\r\n\t\t\t\t\t\t\t\"Control High\": \"0\",\r\n\t\t\t\t\t\t\t\"Control low\": \"0\",\r\n\t\t\t\t\t\t\t\"Control open\": \"0\",\r\n\t\t\t\t\t\t\t\"Control close\": \"0\",\r\n\t\t\t\t\t\t\t\"Between Group Difference\": \"0\"\r\n\t\t\t\t\t\t},\r\n\t\t\t\t\t\t{\r\n\t\t\t\t\t\t\t\"category\": \"3 Months\",\r\n\t\t\t\t\t\t\t\"EBV\": \"22.63\",\r\n\t\t\t\t\t\t\t\"Control\": \"-17.34\",\r\n\t\t\t\t\t\t\t\"EBV Candle High\": \"33\",\r\n\t\t\t\t\t\t\t\"EBVCandle Low\": \"12\",\r\n\t\t\t\t\t\t\t\"EBV open\": \"33\",\r\n\t\t\t\t\t\t\t\"EBV close\": \"12\",\r\n\t\t\t\t\t\t\t\"Control High\": \"-9.9\",\r\n\t\t\t\t\t\t\t\"Control low\": \"-25\",\r\n\t\t\t\t\t\t\t\"Control open\": \"-9.9\",\r\n\t\t\t\t\t\t\t\"Control close\": \"-25\",\r\n\t\t\t\t\t\t\t\"Between Group Difference\": \"39.97\"\r\n\t\t\t\t\t\t},\r\n\t\t\t\t\t\t{\r\n\t\t\t\t\t\t\t\"category\": \"6 Months\",\r\n\t\t\t\t\t\t\t\"EBV\": \"21.26\",\r\n\t\t\t\t\t\t\t\"Control\": \"-7.06\",\r\n\t\t\t\t\t\t\t\"EBV Candle High\": \"29\",\r\n\t\t\t\t\t\t\t\"EBVCandle Low\": \"12\",\r\n\t\t\t\t\t\t\t\"EBV open\": \"29\",\r\n\t\t\t\t\t\t\t\"EBV close\": \"12\",\r\n\t\t\t\t\t\t\t\"Control High\": \".5\",\r\n\t\t\t\t\t\t\t\"Control low\": \"-14.7\",\r\n\t\t\t\t\t\t\t\"Control open\": \".5\",\r\n\t\t\t\t\t\t\t\"Control close\": \"-14.7\",\r\n\t\t\t\t\t\t\t\"Between Group Difference\": \"28.32\"\r\n\t\t\t\t\t\t}\r\n\t\t\t\t\t]\r\n\t\t\t\t}\r\n\t\t\t);\r\n\t\t<\/script>\r\n\t<\/head>\r\n\t<body>\r\n\t\t<div id=\"impact-6mwd\" style=\"width: 100%; height: 400px; background-color: #FFFFFF;\" ><\/div>\r\n\t<\/body>\r\n<\/html><\/p> <\/div>\n<\/div>\n<!-- \/module text --> <\/div>\n <div data-lazy=\"1\" class=\"module_column sub_column col3-1 tb_gqfc225\">\n <!-- module text -->\n<div class=\"module module-text tb_uj4n492 \" data-lazy=\"1\">\n <div class=\"tb_text_wrap\">\n <h5 style=\"text-align: center;\">Change in SGRQ<\/h5>\n<p style=\"text-align: center;\"><!DOCTYPE html>\r\n<html>\r\n\t<head>\r\n\t\t<title>IMPACT - SGRQ - Line | amCharts<\/title>\r\n\t\t<meta name=\"description\" content=\"chart created using amCharts live editor\" \/>\r\n\t\t\r\n\t\t<!-- amCharts javascript sources -->\r\n\t\t<script type=\"text\/javascript\" src=\"https:\/\/www.amcharts.com\/lib\/3\/amcharts.js\"><\/script>\r\n\t\t<script type=\"text\/javascript\" src=\"https:\/\/cdn.amcharts.com\/lib\/3\/serial.js\"><\/script>\r\n\t\t<script type=\"text\/javascript\" src=\"https:\/\/www.amcharts.com\/lib\/3\/themes\/light.js\"><\/script>\r\n\t\t\r\n\r\n\t\t<!-- amCharts javascript code -->\r\n\t\t<script type=\"text\/javascript\">\r\n\t\t\tAmCharts.makeChart(\"impact-SGRQ\",\r\n\t\t\t\t{\r\n \"hideCredits\": \"true\",\r\n\t\t\t\t\t\"type\": \"serial\",\r\n\t\t\t\t\t\"categoryField\": \"category\",\r\n\t\t\t\t\t\"autoMarginOffset\": 0,\r\n\t\t\t\t\t\"autoMargins\": false,\r\n\t\t\t\t\t\"marginBottom\": 32,\r\n\t\t\t\t\t\"marginLeft\": 75,\r\n\t\t\t\t\t\"marginTop\": 65,\r\n\t\t\t\t\t\"sequencedAnimation\": false,\r\n\t\t\t\t\t\"startDuration\": 2,\r\n\t\t\t\t\t\"startEffect\": \"easeOutSine\",\r\n\t\t\t\t\t\"accessibleTitle\": \"changeinsgrqpoints\",\r\n\t\t\t\t\t\"backgroundAlpha\": 0.8,\r\n\t\t\t\t\t\"fontFamily\": \"Arial\",\r\n\t\t\t\t\t\"fontSize\": 14,\r\n\t\t\t\t\t\"pathToImages\": \"http:\/\/cdn.amcharts.com\/lib\/3\/images\/\",\r\n\t\t\t\t\t\"percentPrecision\": 1,\r\n\t\t\t\t\t\"precision\": 1,\r\n\t\t\t\t\t\"theme\": \"light\",\r\n\t\t\t\t\t\"categoryAxis\": {\r\n\t\t\t\t\t\t\"classNameField\": \"\",\r\n\t\t\t\t\t\t\"gridPosition\": \"start\",\r\n\t\t\t\t\t\t\"axisThickness\": 0,\r\n\t\t\t\t\t\t\"boldLabels\": true,\r\n\t\t\t\t\t\t\"centerLabels\": true,\r\n\t\t\t\t\t\t\"fontSize\": 14,\r\n\t\t\t\t\t\t\"gridColor\": \"#FFFFFF\",\r\n\t\t\t\t\t\t\"tickLength\": 0,\r\n\t\t\t\t\t\t\"title\": \"\"\r\n\t\t\t\t\t},\r\n\t\t\t\t\t\"trendLines\": [],\r\n\t\t\t\t\t\"graphs\": [\r\n\t\t\t\t\t\t{\r\n\t\t\t\t\t\t\t\"accessibleLabel\": \"IMPACT - SGRQ - Change from Baseline\",\r\n\t\t\t\t\t\t\t\"balloonText\": \"\",\r\n\t\t\t\t\t\t\t\"closeField\": \"EBV close\",\r\n\t\t\t\t\t\t\t\"clustered\": false,\r\n\t\t\t\t\t\t\t\"columnWidth\": 0,\r\n\t\t\t\t\t\t\t\"dashLengthField\": \"column-2\",\r\n\t\t\t\t\t\t\t\"fillAlphas\": 1,\r\n\t\t\t\t\t\t\t\"fillColors\": 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false\r\n\t\t\t\t\t\t},\r\n\t\t\t\t\t\t{\r\n\t\t\t\t\t\t\t\"accessibleLabel\": \"IMPACT - SGRQ - Change from Baseline\",\r\n\t\t\t\t\t\t\t\"balloonText\": \"\",\r\n\t\t\t\t\t\t\t\"bullet\": \"triangleUp\",\r\n\t\t\t\t\t\t\t\"dashLength\": 3,\r\n\t\t\t\t\t\t\t\"id\": \"AmGraph-5\",\r\n\t\t\t\t\t\t\t\"lineColor\": \"#FF5C39\",\r\n\t\t\t\t\t\t\t\"lineThickness\": 3,\r\n\t\t\t\t\t\t\t\"markerType\": \"triangleUp\",\r\n\t\t\t\t\t\t\t\"showBalloon\": false,\r\n\t\t\t\t\t\t\t\"title\": \"Between Group Difference\",\r\n\t\t\t\t\t\t\t\"valueField\": \"Between Group Difference\"\r\n\t\t\t\t\t\t}\r\n\t\t\t\t\t],\r\n\t\t\t\t\t\"guides\": [],\r\n\t\t\t\t\t\"valueAxes\": [\r\n\t\t\t\t\t\t{\r\n\t\t\t\t\t\t\t\"axisFrequency\": 2,\r\n\t\t\t\t\t\t\t\"id\": \"ValueAxis-1\",\r\n\t\t\t\t\t\t\t\"maximum\": 4,\r\n\t\t\t\t\t\t\t\"minimum\": -12,\r\n\t\t\t\t\t\t\t\"minMaxMultiplier\": 6,\r\n\t\t\t\t\t\t\t\"precision\": 1,\r\n\t\t\t\t\t\t\t\"unit\": \"\",\r\n\t\t\t\t\t\t\t\"autoGridCount\": false,\r\n\t\t\t\t\t\t\t\"gridCount\": 8,\r\n\t\t\t\t\t\t\t\"minVerticalGap\": 39,\r\n\t\t\t\t\t\t\t\"title\": \"Points (pts)\"\r\n\t\t\t\t\t\t}\r\n\t\t\t\t\t],\r\n\t\t\t\t\t\"allLabels\": [\r\n\t\t\t\t\t\t{\r\n\t\t\t\t\t\t\t\"id\": \"Label-1\",\r\n\t\t\t\t\t\t\t\"text\": \"p<0.001\",\r\n\t\t\t\t\t\t\t\"x\": \"76%\",\r\n\t\t\t\t\t\t\t\"y\": \"75%\"\r\n\t\t\t\t\t\t},\r\n\t\t\t\t\t\t{\r\n\t\t\t\t\t\t\t\"id\": \"Label-2\",\r\n\t\t\t\t\t\t\t\"text\": \"p<0.001\",\r\n\t\t\t\t\t\t\t\"x\": \"50%\",\r\n\t\t\t\t\t\t\t\"y\": \"82%\"\r\n\t\t\t\t\t\t}\r\n\t\t\t\t\t],\r\n\t\t\t\t\t\"balloon\": {\r\n\t\t\t\t\t\t\"borderThickness\": 1\r\n\t\t\t\t\t},\r\n\t\t\t\t\t\"legend\": {\r\n\t\t\t\t\t\t\"enabled\": true,\r\n\t\t\t\t\t\t\"switchable\": false,\r\n\t\t\t\t\t\t\"tabIndex\": 8,\r\n\t\t\t\t\t\t\"valueAlign\": \"left\"\r\n\t\t\t\t\t},\r\n\t\t\t\t\t\"titles\": [],\r\n\t\t\t\t\t\"dataProvider\": [\r\n\t\t\t\t\t\t{\r\n\t\t\t\t\t\t\t\"category\": \"Baseline\",\r\n\t\t\t\t\t\t\t\"EBV\": \"0\",\r\n\t\t\t\t\t\t\t\"Control\": \"0\",\r\n\t\t\t\t\t\t\t\"EBV Candle High\": \"0\",\r\n\t\t\t\t\t\t\t\"EBVCandle Low\": \"0\",\r\n\t\t\t\t\t\t\t\"EBV open\": \"0\",\r\n\t\t\t\t\t\t\t\"EBV close\": \"0\",\r\n\t\t\t\t\t\t\t\"Control High\": \"0\",\r\n\t\t\t\t\t\t\t\"Control low\": \"0\",\r\n\t\t\t\t\t\t\t\"Control open\": \"0\",\r\n\t\t\t\t\t\t\t\"Control close\": \"0\",\r\n\t\t\t\t\t\t\t\"Between Group Difference\": \"0\"\r\n\t\t\t\t\t\t},\r\n\t\t\t\t\t\t{\r\n\t\t\t\t\t\t\t\"category\": \"3 Months\",\r\n\t\t\t\t\t\t\t\"EBV\": \"-8.63\",\r\n\t\t\t\t\t\t\t\"Control\": \"1.01\",\r\n\t\t\t\t\t\t\t\"EBV Candle High\": \"-6.75\",\r\n\t\t\t\t\t\t\t\"EBVCandle Low\": \"-10.3\",\r\n\t\t\t\t\t\t\t\"EBV open\": \"-6.75\",\r\n\t\t\t\t\t\t\t\"EBV close\": \"-10.3\",\r\n\t\t\t\t\t\t\t\"Control High\": \"2.25\",\r\n\t\t\t\t\t\t\t\"Control low\": \"-.4\",\r\n\t\t\t\t\t\t\t\"Control open\": \"2.25\",\r\n\t\t\t\t\t\t\t\"Control close\": \"-.4\",\r\n\t\t\t\t\t\t\t\"Between Group Difference\": \"-9.64\"\r\n\t\t\t\t\t\t},\r\n\t\t\t\t\t\t{\r\n\t\t\t\t\t\t\t\"category\": \"6 Months\",\r\n\t\t\t\t\t\t\t\"EBV\": \"-6.84\",\r\n\t\t\t\t\t\t\t\"Control\": \"0.63\",\r\n\t\t\t\t\t\t\t\"EBV Candle High\": \"-5.25\",\r\n\t\t\t\t\t\t\t\"EBVCandle Low\": \"-8.5\",\r\n\t\t\t\t\t\t\t\"EBV open\": \"-5.25\",\r\n\t\t\t\t\t\t\t\"EBV close\": \"-8.5\",\r\n\t\t\t\t\t\t\t\"Control High\": \"2\",\r\n\t\t\t\t\t\t\t\"Control low\": \"-.75\",\r\n\t\t\t\t\t\t\t\"Control open\": \"2\",\r\n\t\t\t\t\t\t\t\"Control close\": \"-.75\",\r\n\t\t\t\t\t\t\t\"Between Group Difference\": \"-7.47\"\r\n\t\t\t\t\t\t}\r\n\t\t\t\t\t]\r\n\t\t\t\t}\r\n\t\t\t);\r\n\t\t<\/script>\r\n\t<\/head>\r\n\t<body>\r\n\t\t<div id=\"impact-SGRQ\" style=\"width: 100%; height: 400px; background-color: #FFFFFF;\" ><\/div>\r\n\t<\/body>\r\n<\/html><\/p> <\/div>\n<\/div>\n<!-- \/module text --> <\/div>\n <div data-lazy=\"1\" class=\"module_column sub_column col3-1 tb_pdv8225 last\">\n <!-- module text -->\n<div class=\"module module-text tb_as6s700 \" data-lazy=\"1\">\n <div class=\"tb_text_wrap\">\n <h5 style=\"text-align: center;\">Change in RV<\/h5>\n<p style=\"text-align: center;\"><!DOCTYPE html>\r\n<html>\r\n\t<head>\r\n\t\t<title>IMPACT - RV - Line | amCharts<\/title>\r\n\t\t<meta name=\"description\" content=\"chart created using amCharts live editor\" \/>\r\n\t\t\r\n\t\t<!-- amCharts javascript sources -->\r\n\t\t<script type=\"text\/javascript\" src=\"https:\/\/www.amcharts.com\/lib\/3\/amcharts.js\"><\/script>\r\n\t\t<script type=\"text\/javascript\" src=\"https:\/\/cdn.amcharts.com\/lib\/3\/serial.js\"><\/script>\r\n\t\t<script type=\"text\/javascript\" src=\"https:\/\/www.amcharts.com\/lib\/3\/themes\/light.js\"><\/script>\r\n\t\t\r\n\r\n\t\t<!-- amCharts javascript code -->\r\n\t\t<script type=\"text\/javascript\">\r\n\t\t\tAmCharts.makeChart(\"impact-RV\",\r\n\t\t\t\t{\r\n \"hideCredits\": \"true\",\r\n\t\t\t\t\t\"type\": \"serial\",\r\n\t\t\t\t\t\"categoryField\": \"category\",\r\n\t\t\t\t\t\"autoMarginOffset\": 0,\r\n\t\t\t\t\t\"autoMargins\": false,\r\n\t\t\t\t\t\"marginBottom\": 32,\r\n\t\t\t\t\t\"marginLeft\": 75,\r\n\t\t\t\t\t\"marginTop\": 65,\r\n\t\t\t\t\t\"sequencedAnimation\": false,\r\n\t\t\t\t\t\"startDuration\": 2,\r\n\t\t\t\t\t\"startEffect\": \"easeOutSine\",\r\n\t\t\t\t\t\"accessibleTitle\": \"changeinrvmilliliters\",\r\n\t\t\t\t\t\"backgroundAlpha\": 0.8,\r\n\t\t\t\t\t\"fontFamily\": \"Arial\",\r\n\t\t\t\t\t\"fontSize\": 14,\r\n\t\t\t\t\t\"pathToImages\": \"http:\/\/cdn.amcharts.com\/lib\/3\/images\/\",\r\n\t\t\t\t\t\"percentPrecision\": 1,\r\n\t\t\t\t\t\"precision\": 1,\r\n\t\t\t\t\t\"theme\": \"light\",\r\n\t\t\t\t\t\"categoryAxis\": {\r\n\t\t\t\t\t\t\"classNameField\": \"\",\r\n\t\t\t\t\t\t\"gridPosition\": \"start\",\r\n\t\t\t\t\t\t\"axisThickness\": 0,\r\n\t\t\t\t\t\t\"boldLabels\": true,\r\n\t\t\t\t\t\t\"centerLabels\": true,\r\n\t\t\t\t\t\t\"fontSize\": 14,\r\n\t\t\t\t\t\t\"gridColor\": \"#FFFFFF\",\r\n\t\t\t\t\t\t\"tickLength\": 0,\r\n\t\t\t\t\t\t\"title\": \"\"\r\n\t\t\t\t\t},\r\n\t\t\t\t\t\"trendLines\": [],\r\n\t\t\t\t\t\"graphs\": [\r\n\t\t\t\t\t\t{\r\n\t\t\t\t\t\t\t\"accessibleLabel\": \"IMPACT - RV- Change from Baseline\",\r\n\t\t\t\t\t\t\t\"balloonText\": \"\",\r\n\t\t\t\t\t\t\t\"closeField\": \"EBV close\",\r\n\t\t\t\t\t\t\t\"clustered\": false,\r\n\t\t\t\t\t\t\t\"columnWidth\": 0,\r\n\t\t\t\t\t\t\t\"dashLengthField\": \"column-2\",\r\n\t\t\t\t\t\t\t\"fillAlphas\": 1,\r\n\t\t\t\t\t\t\t\"fillColors\": \"#000000\",\r\n\t\t\t\t\t\t\t\"fixedColumnWidth\": 2,\r\n\t\t\t\t\t\t\t\"highField\": \"EBV Candle High\",\r\n\t\t\t\t\t\t\t\"id\": \"AmGraph-2\",\r\n\t\t\t\t\t\t\t\"labelText\": \"\",\r\n\t\t\t\t\t\t\t\"lineAlpha\": 0,\r\n\t\t\t\t\t\t\t\"lineColor\": \"#FF5C39\",\r\n\t\t\t\t\t\t\t\"lowField\": \"EBVCandle Low\",\r\n\t\t\t\t\t\t\t\"minBulletSize\": 0,\r\n\t\t\t\t\t\t\t\"minDistance\": 0,\r\n\t\t\t\t\t\t\t\"negativeBase\": 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Baseline\",\r\n\t\t\t\t\t\t\t\"valueField\": \"EBV\"\r\n\t\t\t\t\t\t},\r\n\t\t\t\t\t\t{\r\n\t\t\t\t\t\t\t\"accessibleLabel\": \"IMPACT - RV- Change from Baseline\",\r\n\t\t\t\t\t\t\t\"balloonText\": \"\",\r\n\t\t\t\t\t\t\t\"bullet\": \"round\",\r\n\t\t\t\t\t\t\t\"dashLength\": 10,\r\n\t\t\t\t\t\t\t\"id\": \"Control\",\r\n\t\t\t\t\t\t\t\"lineColor\": \"#3095B4\",\r\n\t\t\t\t\t\t\t\"lineThickness\": 3,\r\n\t\t\t\t\t\t\t\"markerType\": \"circle\",\r\n\t\t\t\t\t\t\t\"showBalloon\": false,\r\n\t\t\t\t\t\t\t\"title\": \"Control Group from Baseline\",\r\n\t\t\t\t\t\t\t\"valueField\": \"Control\"\r\n\t\t\t\t\t\t},\r\n\t\t\t\t\t\t{\r\n\t\t\t\t\t\t\t\"accessibleLabel\": \"IMPACT - RV- Change from Baseline\",\r\n\t\t\t\t\t\t\t\"balloonText\": \"\",\r\n\t\t\t\t\t\t\t\"bulletBorderThickness\": 3,\r\n\t\t\t\t\t\t\t\"closeField\": \"Control close\",\r\n\t\t\t\t\t\t\t\"fillColors\": \"#000000\",\r\n\t\t\t\t\t\t\t\"fixedColumnWidth\": 1,\r\n\t\t\t\t\t\t\t\"highField\": \"Control High\",\r\n\t\t\t\t\t\t\t\"id\": \"AmGraph-4\",\r\n\t\t\t\t\t\t\t\"legendAlpha\": 0,\r\n\t\t\t\t\t\t\t\"lineColor\": \"#000000\",\r\n\t\t\t\t\t\t\t\"lowField\": \"Control low\",\r\n\t\t\t\t\t\t\t\"openField\": \"Control open\",\r\n\t\t\t\t\t\t\t\"showBalloon\": false,\r\n\t\t\t\t\t\t\t\"switchable\": false,\r\n\t\t\t\t\t\t\t\"title\": \"graph 4\",\r\n\t\t\t\t\t\t\t\"type\": \"candlestick\",\r\n\t\t\t\t\t\t\t\"valueField\": \"Control close\",\r\n\t\t\t\t\t\t\t\"visibleInLegend\": false\r\n\t\t\t\t\t\t},\r\n\t\t\t\t\t\t{\r\n\t\t\t\t\t\t\t\"accessibleLabel\": \"IMPACT - RV- Change from Baseline\",\r\n\t\t\t\t\t\t\t\"balloonText\": \"\",\r\n\t\t\t\t\t\t\t\"bullet\": \"triangleUp\",\r\n\t\t\t\t\t\t\t\"dashLength\": 3,\r\n\t\t\t\t\t\t\t\"id\": \"AmGraph-5\",\r\n\t\t\t\t\t\t\t\"lineColor\": \"#FF5C39\",\r\n\t\t\t\t\t\t\t\"lineThickness\": 3,\r\n\t\t\t\t\t\t\t\"markerType\": \"triangleUp\",\r\n\t\t\t\t\t\t\t\"showBalloon\": false,\r\n\t\t\t\t\t\t\t\"title\": \"Between Group Difference\",\r\n\t\t\t\t\t\t\t\"valueField\": \"Between Group Difference\"\r\n\t\t\t\t\t\t}\r\n\t\t\t\t\t],\r\n\t\t\t\t\t\"guides\": [],\r\n\t\t\t\t\t\"valueAxes\": [\r\n\t\t\t\t\t\t{\r\n\t\t\t\t\t\t\t\"axisFrequency\": 2,\r\n\t\t\t\t\t\t\t\"id\": \"ValueAxis-1\",\r\n\t\t\t\t\t\t\t\"maximum\": 300,\r\n\t\t\t\t\t\t\t\"minimum\": -700,\r\n\t\t\t\t\t\t\t\"minMaxMultiplier\": 6,\r\n\t\t\t\t\t\t\t\"unit\": \"\",\r\n\t\t\t\t\t\t\t\"autoGridCount\": false,\r\n\t\t\t\t\t\t\t\"gridCount\": 11,\r\n\t\t\t\t\t\t\t\"minVerticalGap\": 39,\r\n\t\t\t\t\t\t\t\"title\": \"Milliliters (mL)\"\r\n\t\t\t\t\t\t}\r\n\t\t\t\t\t],\r\n\t\t\t\t\t\"allLabels\": [\r\n\t\t\t\t\t\t{\r\n\t\t\t\t\t\t\t\"id\": \"Label-1\",\r\n\t\t\t\t\t\t\t\"text\": \"p=0.015\",\r\n\t\t\t\t\t\t\t\"x\": \"76%\",\r\n\t\t\t\t\t\t\t\"y\": \"83%\"\r\n\t\t\t\t\t\t},\r\n\t\t\t\t\t\t{\r\n\t\t\t\t\t\t\t\"id\": \"Label-2\",\r\n\t\t\t\t\t\t\t\"text\": \"p=0.011\",\r\n\t\t\t\t\t\t\t\"x\": \"50%\",\r\n\t\t\t\t\t\t\t\"y\": \"83%\"\r\n\t\t\t\t\t\t}\r\n\t\t\t\t\t],\r\n\t\t\t\t\t\"balloon\": {\r\n\t\t\t\t\t\t\"borderThickness\": 1\r\n\t\t\t\t\t},\r\n\t\t\t\t\t\"legend\": {\r\n\t\t\t\t\t\t\"enabled\": true,\r\n\t\t\t\t\t\t\"switchable\": false,\r\n\t\t\t\t\t\t\"tabIndex\": 8,\r\n\t\t\t\t\t\t\"valueAlign\": \"left\"\r\n\t\t\t\t\t},\r\n\t\t\t\t\t\"titles\": [],\r\n\t\t\t\t\t\"dataProvider\": [\r\n\t\t\t\t\t\t{\r\n\t\t\t\t\t\t\t\"category\": \"Baseline\",\r\n\t\t\t\t\t\t\t\"EBV\": \"0\",\r\n\t\t\t\t\t\t\t\"Control\": \"0\",\r\n\t\t\t\t\t\t\t\"EBV Candle High\": \"0\",\r\n\t\t\t\t\t\t\t\"EBVCandle Low\": \"0\",\r\n\t\t\t\t\t\t\t\"EBV open\": \"0\",\r\n\t\t\t\t\t\t\t\"EBV close\": \"0\",\r\n\t\t\t\t\t\t\t\"Control High\": \"0\",\r\n\t\t\t\t\t\t\t\"Control low\": \"0\",\r\n\t\t\t\t\t\t\t\"Control open\": \"0\",\r\n\t\t\t\t\t\t\t\"Control close\": \"0\",\r\n\t\t\t\t\t\t\t\"Between Group Difference\": \"0\"\r\n\t\t\t\t\t\t},\r\n\t\t\t\t\t\t{\r\n\t\t\t\t\t\t\t\"category\": \"3 Months\",\r\n\t\t\t\t\t\t\t\"EBV\": \"-420\",\r\n\t\t\t\t\t\t\t\"Control\": \"50\",\r\n\t\t\t\t\t\t\t\"EBV Candle High\": \"-280\",\r\n\t\t\t\t\t\t\t\"EBVCandle Low\": \"-560\",\r\n\t\t\t\t\t\t\t\"EBV open\": \"-280\",\r\n\t\t\t\t\t\t\t\"EBV close\": \"-560\",\r\n\t\t\t\t\t\t\t\"Control High\": \"175\",\r\n\t\t\t\t\t\t\t\"Control low\": \"-75\",\r\n\t\t\t\t\t\t\t\"Control open\": \"175\",\r\n\t\t\t\t\t\t\t\"Control close\": \"-75\",\r\n\t\t\t\t\t\t\t\"Between Group Difference\": \"-470\"\r\n\t\t\t\t\t\t},\r\n\t\t\t\t\t\t{\r\n\t\t\t\t\t\t\t\"category\": \"6 Months\",\r\n\t\t\t\t\t\t\t\"EBV\": \"-480\",\r\n\t\t\t\t\t\t\t\"Control\": \"-60\",\r\n\t\t\t\t\t\t\t\"EBV Candle High\": \"-325\",\r\n\t\t\t\t\t\t\t\"EBVCandle Low\": \"-615\",\r\n\t\t\t\t\t\t\t\"EBV open\": \"-325\",\r\n\t\t\t\t\t\t\t\"EBV close\": \"-615\",\r\n\t\t\t\t\t\t\t\"Control High\": \"55\",\r\n\t\t\t\t\t\t\t\"Control low\": \"-180\",\r\n\t\t\t\t\t\t\t\"Control open\": \"55\",\r\n\t\t\t\t\t\t\t\"Control close\": \"-180\",\r\n\t\t\t\t\t\t\t\"Between Group Difference\": \"-420\"\r\n\t\t\t\t\t\t}\r\n\t\t\t\t\t]\r\n\t\t\t\t}\r\n\t\t\t);\r\n\t\t<\/script>\r\n\t<\/head>\r\n\t<body>\r\n\t\t<div id=\"impact-RV\" style=\"width: 100%; height: 400px; background-color: #FFFFFF;\" ><\/div>\r\n\t<\/body>\r\n<\/html><\/p> <\/div>\n<\/div>\n<!-- \/module text --> <\/div>\n <\/div>\n <div data-lazy=\"1\" class=\"module_subrow themify_builder_sub_row tf_w col_align_top tb_col_count_3 tb_hu6u780\">\n <div data-lazy=\"1\" class=\"module_column sub_column col3-1 tb_ik0q782 first\">\n <!-- module text -->\n<div class=\"module module-text tb_bftx782 \" data-lazy=\"1\">\n <div class=\"tb_text_wrap\">\n <h5 style=\"text-align: center;\">Change in FEV<sub>1<\/sub><\/h5>\n<p style=\"text-align: center;\"><!DOCTYPE html>\r\n<html>\r\n\t<head>\r\n\t\t<title>IMPACT - FEV1 - Line | amCharts<\/title>\r\n\t\t<meta name=\"description\" content=\"chart created using amCharts live editor\" \/>\r\n\t\t\r\n\t\t<!-- amCharts javascript sources -->\r\n\t\t<script type=\"text\/javascript\" src=\"https:\/\/www.amcharts.com\/lib\/3\/amcharts.js\"><\/script>\r\n\t\t<script type=\"text\/javascript\" src=\"https:\/\/cdn.amcharts.com\/lib\/3\/serial.js\"><\/script>\r\n\t\t<script type=\"text\/javascript\" src=\"https:\/\/www.amcharts.com\/lib\/3\/themes\/light.js\"><\/script>\r\n\t\t\r\n\r\n\t\t<!-- amCharts javascript code -->\r\n\t\t<script type=\"text\/javascript\">\r\n\t\t\tAmCharts.makeChart(\"impact-FEV1\",\r\n\t\t\t\t{\r\n \"hideCredits\": \"true\",\r\n\t\t\t\t\t\"type\": \"serial\",\r\n\t\t\t\t\t\"categoryField\": \"category\",\r\n\t\t\t\t\t\"autoMarginOffset\": 0,\r\n\t\t\t\t\t\"autoMargins\": false,\r\n\t\t\t\t\t\"marginBottom\": 32,\r\n\t\t\t\t\t\"marginLeft\": 75,\r\n\t\t\t\t\t\"marginTop\": 65,\r\n\t\t\t\t\t\"sequencedAnimation\": false,\r\n\t\t\t\t\t\"startDuration\": 2,\r\n\t\t\t\t\t\"startEffect\": \"easeOutSine\",\r\n\t\t\t\t\t\"accessibleTitle\": \"changeinfev1milliliters\",\r\n\t\t\t\t\t\"backgroundAlpha\": 0.8,\r\n\t\t\t\t\t\"fontFamily\": \"Arial\",\r\n\t\t\t\t\t\"fontSize\": 14,\r\n\t\t\t\t\t\"pathToImages\": \"http:\/\/cdn.amcharts.com\/lib\/3\/images\/\",\r\n\t\t\t\t\t\"percentPrecision\": 1,\r\n\t\t\t\t\t\"precision\": 1,\r\n\t\t\t\t\t\"theme\": \"light\",\r\n\t\t\t\t\t\"categoryAxis\": {\r\n\t\t\t\t\t\t\"classNameField\": \"\",\r\n\t\t\t\t\t\t\"gridPosition\": \"start\",\r\n\t\t\t\t\t\t\"axisThickness\": 0,\r\n\t\t\t\t\t\t\"boldLabels\": true,\r\n\t\t\t\t\t\t\"centerLabels\": true,\r\n\t\t\t\t\t\t\"fontSize\": 14,\r\n\t\t\t\t\t\t\"gridColor\": \"#FFFFFF\",\r\n\t\t\t\t\t\t\"tickLength\": 0,\r\n\t\t\t\t\t\t\"title\": \"\"\r\n\t\t\t\t\t},\r\n\t\t\t\t\t\"trendLines\": [],\r\n\t\t\t\t\t\"graphs\": [\r\n\t\t\t\t\t\t{\r\n\t\t\t\t\t\t\t\"accessibleLabel\": \"IMPACT - FEV1- Change from Baseline\",\r\n\t\t\t\t\t\t\t\"balloonText\": \"\",\r\n\t\t\t\t\t\t\t\"closeField\": \"EBV close\",\r\n\t\t\t\t\t\t\t\"clustered\": false,\r\n\t\t\t\t\t\t\t\"columnWidth\": 0,\r\n\t\t\t\t\t\t\t\"dashLengthField\": \"column-2\",\r\n\t\t\t\t\t\t\t\"fillAlphas\": 1,\r\n\t\t\t\t\t\t\t\"fillColors\": \"#000000\",\r\n\t\t\t\t\t\t\t\"fixedColumnWidth\": 2,\r\n\t\t\t\t\t\t\t\"highField\": \"EBV Candle High\",\r\n\t\t\t\t\t\t\t\"id\": \"AmGraph-2\",\r\n\t\t\t\t\t\t\t\"labelText\": \"\",\r\n\t\t\t\t\t\t\t\"lineAlpha\": 0,\r\n\t\t\t\t\t\t\t\"lineColor\": \"#FF5C39\",\r\n\t\t\t\t\t\t\t\"lowField\": \"EBVCandle Low\",\r\n\t\t\t\t\t\t\t\"minBulletSize\": 0,\r\n\t\t\t\t\t\t\t\"minDistance\": 0,\r\n\t\t\t\t\t\t\t\"negativeBase\": -1,\r\n\t\t\t\t\t\t\t\"negativeFillAlphas\": 0,\r\n\t\t\t\t\t\t\t\"negativeLineAlpha\": 0,\r\n\t\t\t\t\t\t\t\"openField\": \"EBV open\",\r\n\t\t\t\t\t\t\t\"showBalloon\": false,\r\n\t\t\t\t\t\t\t\"title\": \"graph 2\",\r\n\t\t\t\t\t\t\t\"topRadius\": 0,\r\n\t\t\t\t\t\t\t\"type\": \"candlestick\",\r\n\t\t\t\t\t\t\t\"valueField\": \"EBV close\",\r\n\t\t\t\t\t\t\t\"visibleInLegend\": false\r\n\t\t\t\t\t\t},\r\n\t\t\t\t\t\t{\r\n\t\t\t\t\t\t\t\"accessibleLabel\": \"IMPACT - FEV1- Change from Baseline\",\r\n\t\t\t\t\t\t\t\"balloonText\": \"\",\r\n\t\t\t\t\t\t\t\"bullet\": \"square\",\r\n\t\t\t\t\t\t\t\"classNameField\": \"\",\r\n\t\t\t\t\t\t\t\"id\": \"EBV\",\r\n\t\t\t\t\t\t\t\"labelOffset\": 3,\r\n\t\t\t\t\t\t\t\"labelText\": \"\",\r\n\t\t\t\t\t\t\t\"legendAlpha\": 1,\r\n\t\t\t\t\t\t\t\"lineColor\": \"#4F2D7F\",\r\n\t\t\t\t\t\t\t\"lineThickness\": 3,\r\n\t\t\t\t\t\t\t\"markerType\": \"square\",\r\n\t\t\t\t\t\t\t\"showBalloon\": false,\r\n\t\t\t\t\t\t\t\"title\": \"Zephyr Valve Group from Baseline\",\r\n\t\t\t\t\t\t\t\"valueField\": \"EBV\"\r\n\t\t\t\t\t\t},\r\n\t\t\t\t\t\t{\r\n\t\t\t\t\t\t\t\"accessibleLabel\": \"IMPACT - FEV1- Change from Baseline\",\r\n\t\t\t\t\t\t\t\"balloonText\": \"\",\r\n\t\t\t\t\t\t\t\"bullet\": \"round\",\r\n\t\t\t\t\t\t\t\"dashLength\": 10,\r\n\t\t\t\t\t\t\t\"id\": \"Control\",\r\n\t\t\t\t\t\t\t\"lineColor\": \"#3095B4\",\r\n\t\t\t\t\t\t\t\"lineThickness\": 3,\r\n\t\t\t\t\t\t\t\"markerType\": \"circle\",\r\n\t\t\t\t\t\t\t\"showBalloon\": false,\r\n\t\t\t\t\t\t\t\"title\": \"Control Group from Baseline\",\r\n\t\t\t\t\t\t\t\"valueField\": \"Control\"\r\n\t\t\t\t\t\t},\r\n\t\t\t\t\t\t{\r\n\t\t\t\t\t\t\t\"accessibleLabel\": \"IMPACT - FEV1- Change from Baseline\",\r\n\t\t\t\t\t\t\t\"balloonText\": \"\",\r\n\t\t\t\t\t\t\t\"bulletBorderThickness\": 3,\r\n\t\t\t\t\t\t\t\"closeField\": \"Control close\",\r\n\t\t\t\t\t\t\t\"fillColors\": \"#000000\",\r\n\t\t\t\t\t\t\t\"fixedColumnWidth\": 1,\r\n\t\t\t\t\t\t\t\"highField\": \"Control High\",\r\n\t\t\t\t\t\t\t\"id\": \"AmGraph-4\",\r\n\t\t\t\t\t\t\t\"legendAlpha\": 0,\r\n\t\t\t\t\t\t\t\"lineColor\": \"#000000\",\r\n\t\t\t\t\t\t\t\"lowField\": \"Control low\",\r\n\t\t\t\t\t\t\t\"openField\": \"Control open\",\r\n\t\t\t\t\t\t\t\"showBalloon\": false,\r\n\t\t\t\t\t\t\t\"switchable\": false,\r\n\t\t\t\t\t\t\t\"title\": \"graph 4\",\r\n\t\t\t\t\t\t\t\"type\": \"candlestick\",\r\n\t\t\t\t\t\t\t\"valueField\": \"Control close\",\r\n\t\t\t\t\t\t\t\"visibleInLegend\": false\r\n\t\t\t\t\t\t},\r\n\t\t\t\t\t\t{\r\n\t\t\t\t\t\t\t\"accessibleLabel\": \"IMPACT - FEV1- Change from Baseline\",\r\n\t\t\t\t\t\t\t\"balloonText\": \"\",\r\n\t\t\t\t\t\t\t\"bullet\": \"triangleUp\",\r\n\t\t\t\t\t\t\t\"dashLength\": 3,\r\n\t\t\t\t\t\t\t\"id\": \"AmGraph-5\",\r\n\t\t\t\t\t\t\t\"lineColor\": \"#FF5C39\",\r\n\t\t\t\t\t\t\t\"lineThickness\": 3,\r\n\t\t\t\t\t\t\t\"markerType\": \"triangleUp\",\r\n\t\t\t\t\t\t\t\"showBalloon\": false,\r\n\t\t\t\t\t\t\t\"title\": \"Between Group Difference\",\r\n\t\t\t\t\t\t\t\"valueField\": \"Between Group Difference\"\r\n\t\t\t\t\t\t}\r\n\t\t\t\t\t],\r\n\t\t\t\t\t\"guides\": [],\r\n\t\t\t\t\t\"valueAxes\": [\r\n\t\t\t\t\t\t{\r\n\t\t\t\t\t\t\t\"axisFrequency\": 2,\r\n\t\t\t\t\t\t\t\"id\": \"ValueAxis-1\",\r\n\t\t\t\t\t\t\t\"maximum\": 200,\r\n\t\t\t\t\t\t\t\"minimum\": -100,\r\n\t\t\t\t\t\t\t\"minMaxMultiplier\": 6,\r\n\t\t\t\t\t\t\t\"unit\": \"\",\r\n\t\t\t\t\t\t\t\"autoGridCount\": false,\r\n\t\t\t\t\t\t\t\"gridCount\": 8,\r\n\t\t\t\t\t\t\t\"minVerticalGap\": 39,\r\n\t\t\t\t\t\t\t\"title\": \"Milliliters (mL)\"\r\n\t\t\t\t\t\t}\r\n\t\t\t\t\t],\r\n\t\t\t\t\t\"allLabels\": [\r\n\t\t\t\t\t\t{\r\n\t\t\t\t\t\t\t\"id\": \"Label-1\",\r\n\t\t\t\t\t\t\t\"text\": \"p<0.001\",\r\n\t\t\t\t\t\t\t\"x\": \"76%\",\r\n\t\t\t\t\t\t\t\"y\": \"26%\"\r\n\t\t\t\t\t\t},\r\n\t\t\t\t\t\t{\r\n\t\t\t\t\t\t\t\"id\": \"Label-2\",\r\n\t\t\t\t\t\t\t\"text\": \"p<0.001\",\r\n\t\t\t\t\t\t\t\"x\": \"50%\",\r\n\t\t\t\t\t\t\t\"y\": \"28%\"\r\n\t\t\t\t\t\t}\r\n\t\t\t\t\t],\r\n\t\t\t\t\t\"balloon\": {\r\n\t\t\t\t\t\t\"borderThickness\": 1\r\n\t\t\t\t\t},\r\n\t\t\t\t\t\"legend\": {\r\n\t\t\t\t\t\t\"enabled\": true,\r\n\t\t\t\t\t\t\"switchable\": false,\r\n\t\t\t\t\t\t\"tabIndex\": 8,\r\n\t\t\t\t\t\t\"valueAlign\": \"left\"\r\n\t\t\t\t\t},\r\n\t\t\t\t\t\"titles\": [],\r\n\t\t\t\t\t\"dataProvider\": [\r\n\t\t\t\t\t\t{\r\n\t\t\t\t\t\t\t\"category\": \"Baseline\",\r\n\t\t\t\t\t\t\t\"EBV\": \"0\",\r\n\t\t\t\t\t\t\t\"Control\": \"0\",\r\n\t\t\t\t\t\t\t\"EBV Candle High\": \"0\",\r\n\t\t\t\t\t\t\t\"EBVCandle Low\": \"0\",\r\n\t\t\t\t\t\t\t\"EBV open\": \"0\",\r\n\t\t\t\t\t\t\t\"EBV close\": \"0\",\r\n\t\t\t\t\t\t\t\"Control High\": \"0\",\r\n\t\t\t\t\t\t\t\"Control low\": \"0\",\r\n\t\t\t\t\t\t\t\"Control open\": \"0\",\r\n\t\t\t\t\t\t\t\"Control close\": \"0\",\r\n\t\t\t\t\t\t\t\"Between Group Difference\": \"0\"\r\n\t\t\t\t\t\t},\r\n\t\t\t\t\t\t{\r\n\t\t\t\t\t\t\t\"category\": \"3 Months\",\r\n\t\t\t\t\t\t\t\"EBV\": \"100\",\r\n\t\t\t\t\t\t\t\"Control\": \"-20\",\r\n\t\t\t\t\t\t\t\"EBV Candle High\": \"130\",\r\n\t\t\t\t\t\t\t\"EBVCandle Low\": \"70\",\r\n\t\t\t\t\t\t\t\"EBV open\": \"130\",\r\n\t\t\t\t\t\t\t\"EBV close\": \"70\",\r\n\t\t\t\t\t\t\t\"Control High\": \"-5\",\r\n\t\t\t\t\t\t\t\"Control low\": \"-35\",\r\n\t\t\t\t\t\t\t\"Control open\": \"-5\",\r\n\t\t\t\t\t\t\t\"Control close\": \"-35\",\r\n\t\t\t\t\t\t\t\"Between Group Difference\": \"120\"\r\n\t\t\t\t\t\t},\r\n\t\t\t\t\t\t{\r\n\t\t\t\t\t\t\t\"category\": \"6 Months\",\r\n\t\t\t\t\t\t\t\"EBV\": \"80\",\r\n\t\t\t\t\t\t\t\"Control\": \"-40\",\r\n\t\t\t\t\t\t\t\"EBV Candle High\": \"110\",\r\n\t\t\t\t\t\t\t\"EBVCandle Low\": \"53\",\r\n\t\t\t\t\t\t\t\"EBV open\": \"110\",\r\n\t\t\t\t\t\t\t\"EBV close\": \"53\",\r\n\t\t\t\t\t\t\t\"Control High\": \"-20\",\r\n\t\t\t\t\t\t\t\"Control low\": \"-60\",\r\n\t\t\t\t\t\t\t\"Control open\": \"-20\",\r\n\t\t\t\t\t\t\t\"Control close\": \"-60\",\r\n\t\t\t\t\t\t\t\"Between Group Difference\": \"120\"\r\n\t\t\t\t\t\t}\r\n\t\t\t\t\t]\r\n\t\t\t\t}\r\n\t\t\t);\r\n\t\t<\/script>\r\n\t<\/head>\r\n\t<body>\r\n\t\t<div id=\"impact-FEV1\" style=\"width: 100%; height: 400px; background-color: #FFFFFF;\" ><\/div>\r\n\t<\/body>\r\n<\/html><\/p> <\/div>\n<\/div>\n<!-- \/module text --> <\/div>\n <div data-lazy=\"1\" class=\"module_column sub_column col3-1 tb_7z0s783\">\n <!-- module text -->\n<div class=\"module module-text tb_e6z3783 \" data-lazy=\"1\">\n <div class=\"tb_text_wrap\">\n <h5 style=\"text-align: center;\">Change in mMRC Dyspnea Score<\/h5>\n<p style=\"text-align: center;\"><!DOCTYPE html>\r\n<html>\r\n\t<head>\r\n\t\t<title>IMPACT - mMRC - Line | amCharts<\/title>\r\n\t\t<meta name=\"description\" content=\"chart created using amCharts live editor\" \/>\r\n\t\t\r\n\t\t<!-- amCharts javascript sources -->\r\n\t\t<script type=\"text\/javascript\" src=\"https:\/\/www.amcharts.com\/lib\/3\/amcharts.js\"><\/script>\r\n\t\t<script type=\"text\/javascript\" src=\"https:\/\/cdn.amcharts.com\/lib\/3\/serial.js\"><\/script>\r\n\t\t<script type=\"text\/javascript\" src=\"https:\/\/www.amcharts.com\/lib\/3\/themes\/light.js\"><\/script>\r\n\t\t\r\n\r\n\t\t<!-- amCharts javascript code -->\r\n\t\t<script type=\"text\/javascript\">\r\n\t\t\tAmCharts.makeChart(\"impact-mMRC\",\r\n\t\t\t\t{\r\n \"hideCredits\": \"true\",\r\n\t\t\t\t\t\"type\": \"serial\",\r\n\t\t\t\t\t\"categoryField\": \"category\",\r\n\t\t\t\t\t\"autoMarginOffset\": 0,\r\n\t\t\t\t\t\"autoMargins\": false,\r\n\t\t\t\t\t\"marginBottom\": 32,\r\n\t\t\t\t\t\"marginLeft\": 75,\r\n\t\t\t\t\t\"marginTop\": 65,\r\n\t\t\t\t\t\"sequencedAnimation\": false,\r\n\t\t\t\t\t\"startDuration\": 2,\r\n\t\t\t\t\t\"startEffect\": \"easeOutSine\",\r\n\t\t\t\t\t\"accessibleTitle\": \"changeinmmrcdyspneascore\",\r\n\t\t\t\t\t\"backgroundAlpha\": 0.8,\r\n\t\t\t\t\t\"fontFamily\": \"Arial\",\r\n\t\t\t\t\t\"fontSize\": 14,\r\n\t\t\t\t\t\"pathToImages\": \"http:\/\/cdn.amcharts.com\/lib\/3\/images\/\",\r\n\t\t\t\t\t\"percentPrecision\": 1,\r\n\t\t\t\t\t\"precision\": 1,\r\n\t\t\t\t\t\"theme\": \"light\",\r\n\t\t\t\t\t\"categoryAxis\": {\r\n\t\t\t\t\t\t\"classNameField\": \"\",\r\n\t\t\t\t\t\t\"gridPosition\": \"start\",\r\n\t\t\t\t\t\t\"axisThickness\": 0,\r\n\t\t\t\t\t\t\"boldLabels\": true,\r\n\t\t\t\t\t\t\"centerLabels\": 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class=\"module module-text tb_u6r8619 \" data-lazy=\"1\">\n <div class=\"tb_text_wrap\">\n <h2 class=\"p1\">Conclusion<\/h2>\n<p class=\"p1\">Patients with homogeneous emphysema can achieve clinically meaningful benefits in lung function, exercise tolerance, and quality of life with endobronchial valve treatment when they are pre-selected for absence of collateral ventilation and have complete lobar occlusion.<\/p> <\/div>\n<\/div>\n<!-- \/module text --><!-- module text -->\n<div class=\"module module-text tb_31w4199 \" data-lazy=\"1\">\n <div class=\"tb_text_wrap\">\n <p>\u00a0<\/p>\n<p>Complications of the Zephyr Endobronchial Valve treatment can include but are not limited to pneumothorax, worsening of COPD symptoms, hemoptysis, pneumonia, dyspnea and, in rare cases, death.<\/p> <\/div>\n<\/div>\n<!-- \/module text --> <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n<!--\/themify_builder_content-->","protected":false},"excerpt":{"rendered":"<p>A multicenter, multinational randomized controlled trial of Zephyr\u00ae Endobronchial Valves in patients with heterogenous emphysema and little to no collateral ventilation.<\/p>\n","protected":false},"author":2,"featured_media":91257,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[192],"tags":[],"class_list":["post-91255","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-clinical-studies-uk-en","has-post-title","has-post-date","has-post-category","has-post-tag","has-post-comment","has-post-author",""],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>IMPACT Clinical Study for Zephyr Valves | Pulmonx<\/title>\n<meta name=\"description\" content=\"The IMPACT clinical study is the first prospective randomized controlled trial of Zephyr\u00ae in patients 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