{"id":74897,"date":"2020-04-15T10:42:23","date_gmt":"2020-04-15T15:42:23","guid":{"rendered":"https:\/\/pulmonx.com\/impact-estudio-clinico\/"},"modified":"2021-05-03T14:42:18","modified_gmt":"2021-05-03T19:42:18","slug":"impact-estudio-clinico","status":"publish","type":"post","link":"https:\/\/pulmonx.com\/es\/impact-estudio-clinico\/","title":{"rendered":"IMPACT Estudio cl\u00ednico"},"content":{"rendered":"\n
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\n \"IMPACT-Estudio-Clinico\" \n <\/div>\n \n \n <\/div>\n\n
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El tratamiento con EBV en pacientes seleccionados con enfisema homog\u00e9neo sin ventilaci\u00f3n colateral produce beneficios cl\u00ednicamente significativos al mejorar la funci\u00f3n pulmonar, la tolerancia al ejercicio y la calidad de vida. Debido a que las opciones de tratamiento disponibles son limitadas para esta poblaci\u00f3n de pacientes, deber\u00eda considerarse el tratamiento con EBV para estos pacientes.3<\/sup><\/a><\/p>\n<\/blockquote>\n <\/div>\n<\/div>\n\n

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\n \n Descargar resumen de ensayos <\/a>\n <\/div>\n <\/div>\n\n <\/div>\n
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Publicado en The American Journal of Respiratory and Critical Care Medicine3<\/sup><\/a><\/h1>\n

El primer ensayo controlado aleatorizado de v\u00e1lvulas endobronquiales Zephyr\u00ae<\/sup> en pacientes con enfisema homog\u00e9neo y poca o ninguna ventilaci\u00f3n colateral (VC).<\/p>\n

M\u00e9todos<\/h3>\n
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    93 pacientes con enfisema homog\u00e9neo confirmados como negativos a la VC con el sistema Chartis\u00ae<\/span><\/sup> y que probablemente responder\u00edan al tratamiento con v\u00e1lvulas Zephyr, que se aleatorizaron en una proporci\u00f3n 1:1 para el tratamiento con v\u00e1lvulas Zephyr o el tratamiento est\u00e1ndar.<\/p>\n<\/li>\n

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    Para los pacientes tratados con v\u00e1lvulas Zephyr, se seleccionaron los l\u00f3bulos afectados a partir de las puntuaciones de destrucci\u00f3n del enfisema y el deterioro de la perfusi\u00f3n regional, y se ocluyeron por completo con v\u00e1lvulas.<\/p>\n<\/li>\n

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    Si los pacientes no experimentaban beneficios, se evaluaba la posici\u00f3n de la v\u00e1lvula a los 30 d\u00edas mediante TC y se retiraba y sustitu\u00eda en caso necesario.<\/p>\n<\/li>\n<\/ul> <\/div>\n<\/div>\n <\/div>\n <\/div>\n <\/div>\n

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    Dise\u00f1o del ensayo<\/h2> <\/div>\n<\/div>\n\n
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    \n \"IMPACT-Study-Summary-Spanish-1\" \n <\/div>\n \n \n <\/div>\n\n
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    Resultados<\/h2> <\/div>\n<\/div>\n
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    Resultados principales en la poblaci\u00f3n por intenci\u00f3n de tratar<\/h4>\n

    Cambio porcentual en el VEF1<\/sub> con respecto al valor inicial transcurridos 3 meses<\/p>\n

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grupo de control n=50<\/h5> <\/div>\n<\/div>\n<!-- \/module text --> <\/div>\n <\/div>\n <div data-lazy=\"1\" class=\"module_subrow themify_builder_sub_row tf_w col_align_top tb_col_count_2 tb_ojvn222\">\n <div data-lazy=\"1\" class=\"module_column sub_column col4-2 tb_akwx224 first\">\n <!-- module text -->\n<div class=\"module module-text tb_vi93559 \" data-lazy=\"1\">\n <div class=\"tb_text_wrap\">\n <h5 style=\"text-align: center;\">Cambio en la DR6<\/h5>\n<p style=\"text-align: center;\"><!DOCTYPE html>\r\n<html>\r\n\t<head>\r\n\t\t<title>IMPACT Study Page - Spanish: IMPACT - 6MWD - Line | amCharts<\/title>\r\n\t\t<meta name=\"description\" content=\"chart created using amCharts live editor\" \/>\r\n\t\t\r\n\t\t<!-- amCharts javascript sources -->\r\n\t\t<script type=\"text\/javascript\" src=\"https:\/\/www.amcharts.com\/lib\/3\/amcharts.js\"><\/script>\r\n\t\t<script type=\"text\/javascript\" src=\"https:\/\/cdn.amcharts.com\/lib\/3\/serial.js\"><\/script>\r\n\t\t<script 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class=\"module_column sub_column col-full tb_gf5k87 first\">\n <!-- module divider -->\n<div class=\"module tf_mw module-divider tb_gb3g584 solid \" style=\"border-width: 1px;border-color: #3095b4;margin-top: 10px;margin-bottom: 40px;\" data-lazy=\"1\">\n <\/div>\n<!-- \/module divider -->\n<!-- module text -->\n<div class=\"module module-text tb_u6r8619 \" data-lazy=\"1\">\n <div class=\"tb_text_wrap\">\n <h2 class=\"p1\">Conclusi\u00f3n<\/h2>\n<p class=\"p1\">Los pacientes con enfisema homog\u00e9neo pueden obtener beneficios cl\u00ednicamente significativos en la funci\u00f3n pulmonar, la tolerancia al ejercicio y la calidad de vida con el tratamiento con v\u00e1lvulas endobronquiales en aquellos casos en que son preseleccionados por ausencia de ventilaci\u00f3n colateral y que presentan una oclusi\u00f3n lobular completa.<\/p> <\/div>\n<\/div>\n<!-- \/module text --><!-- module text -->\n<div class=\"module module-text tb_31w4199 \" data-lazy=\"1\">\n <div class=\"tb_text_wrap\">\n <p> <\/p>\n<p>Entre las complicaciones del tratamiento con la v\u00e1lvula endobronquial Zephyr, se pueden incluir, entre otras, neumot\u00f3rax, empeoramiento de la sintomatolog\u00eda de EPOC, hemoptisis, neumon\u00eda, disnea y, con escasa incidencia, fallecimiento.<\/p> <\/div>\n<\/div>\n<!-- \/module text --> <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n<!--\/themify_builder_content-->","protected":false},"excerpt":{"rendered":"<p>Ensayo controlado aleatorizado, multinacional y multic\u00e9ntrico de v\u00e1lvulas endobronquiales Zephyr\u00ae en pacientes con enfisema heterog\u00e9neo y poca o ninguna ventilaci\u00f3n 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