{"id":82733,"date":"2023-04-26T15:53:08","date_gmt":"2023-04-26T20:53:08","guid":{"rendered":"https:\/\/pulmonx.com\/?page_id=82733"},"modified":"2023-04-26T15:53:10","modified_gmt":"2023-04-26T20:53:10","slug":"klinische-evidenz","status":"publish","type":"page","link":"https:\/\/pulmonx.com\/de\/klinische-evidenz\/","title":{"rendered":"Klinische Evidenz"},"content":{"rendered":"<p><\/p>\n\n<!--themify_builder_content-->\n<div id=\"themify_builder_content-82733\" data-postid=\"82733\" class=\"themify_builder_content themify_builder_content-82733 themify_builder tf_clear\">\n                    <div  data-parallax-bg=\"mobile\" data-css_id=\"a96fda5\" data-lazy=\"1\" class=\"module_row themify_builder_row fullwidth_row_container tb_a96fda5 tb_first tf_w wow\" data-tf-animation=\"fadeIn\">\n                        <div class=\"row_inner col_align_top tb_col_count_1 tf_box tf_rel\">\n                        <div  data-lazy=\"1\" class=\"module_column tb-column col-full tb_69d7692 first\">\n                            <\/div>\n                        <\/div>\n        <\/div>\n                        <div  data-lazy=\"1\" class=\"module_row themify_builder_row tb_104w755 tf_w\">\n                        <div class=\"row_inner col_align_top tb_col_count_1 tf_box tf_rel\">\n                        <div  data-lazy=\"1\" class=\"module_column tb-column col-full tb_udi9757 first\">\n                    <!-- module text -->\n<div  class=\"module module-text tb_knhn986   \" data-lazy=\"1\">\n        <div  class=\"tb_text_wrap\">\n        <h1><strong>&gt;100 wissenschaftliche Ver\u00f6ffentlichungen <\/strong><\/h1>\n<p>Die Ergebnisse zahlreicher randomisierter, klinischer Studien mit dem Zephyr<sup>\u00ae<\/sup>-Ventil zeigen klinisch bedeutsame Vorteile in Bezug auf die Lungenfunktion, die k\u00f6rperliche Leistungsf\u00e4higkeit und die Lebensqualit\u00e4t (QoL).<a style=\"font-size: 15px;\" href=\"\/de\/verweise\/\"><sup>1-5<\/sup><\/a><\/p>    <\/div>\n<\/div>\n<!-- \/module text --><!-- module image -->\n<div  class=\"module module-image tb_tetw383 image-center   tf_mw\" data-lazy=\"1\">\n        <div class=\"image-wrap tf_rel tf_mw\">\n            <img decoding=\"async\" src=\"https:\/\/pulmonx.com\/wp-content\/uploads\/2020\/04\/German-Upward-Staircase-1024x763-650x484.png\" width=\"650\" height=\"484\" class=\"wp-post-image wp-image-74958\" title=\"German-Upward-Staircase\" alt=\"German-Upward-Staircase\" srcset=\"https:\/\/pulmonx.com\/wp-content\/uploads\/2020\/04\/German-Upward-Staircase-1024x763-650x484.png 650w, https:\/\/pulmonx.com\/wp-content\/uploads\/2020\/04\/German-Upward-Staircase-300x224.png 300w, https:\/\/pulmonx.com\/wp-content\/uploads\/2020\/04\/German-Upward-Staircase-1024x763.png 1024w, https:\/\/pulmonx.com\/wp-content\/uploads\/2020\/04\/German-Upward-Staircase-768x572.png 768w, https:\/\/pulmonx.com\/wp-content\/uploads\/2020\/04\/German-Upward-Staircase.png 1220w\" sizes=\"(max-width: 650px) 100vw, 650px\" \/>    \n        <\/div>\n    <!-- \/image-wrap -->\n    \n        <\/div>\n<!-- \/module image -->        <\/div>\n                        <\/div>\n        <\/div>\n                        <div  data-css_id=\"44409ab\" data-lazy=\"1\" class=\"module_row themify_builder_row fullwidth tb_44409ab tf_w\">\n                        <div class=\"row_inner col_align_top tb_col_count_1 tf_box tf_rel\">\n                        <div  data-lazy=\"1\" class=\"module_column tb-column col-full tb_f1af839 first\">\n                            <div  data-lazy=\"1\" class=\"module_subrow themify_builder_sub_row tf_w col_align_top tb_col_count_2 tb_doxp708\">\n                <div  data-lazy=\"1\" class=\"module_column sub_column col4-2 tb_dmq3710 first\">\n                    <!-- module text -->\n<div  class=\"module module-text tb_40up511   \" data-lazy=\"1\">\n        <div  class=\"tb_text_wrap\">\n        <ul>\n<li>4 ver\u00f6ffentlichte RCT mit Anwendung des Zephyr-Ventils und von Chartis<sup>\u00ae<\/sup> zur Vorauswahl der Patienten<a style=\"font-size: 15px;\" href=\"\/de\/verweise\/\"><sup>1-5<\/sup><\/a><\/li>\n<li>Ver\u00f6ffentlicht in The New England Journal of Medicine, The Lancet und in The American Journal of Respiratory and Critical Care Medicine<a style=\"font-size: 15px;\" href=\"\/de\/verweise\/\"><sup>1-5,16<\/sup><\/a><\/li>\n<\/ul>    <\/div>\n<\/div>\n<!-- \/module text -->        <\/div>\n                    <div  data-lazy=\"1\" class=\"module_column sub_column col4-2 tb_svbr710 last\">\n                    <!-- module text -->\n<div  class=\"module module-text tb_gaa0691   \" data-lazy=\"1\">\n        <div  class=\"tb_text_wrap\">\n        <ul>\n<li>Statistisch signifikante und klinisch bedeutsame Verbesserungen im Vergleich zur Standardversorgung in zahlreichen Studien<a style=\"font-size: 15px;\" href=\"\/de\/verweise\/\"><sup>1-4<\/sup><\/a><\/li>\n<li>Behandlungserfolge in Bezug auf verschiedene prim\u00e4re und sekund\u00e4re Endpunkte<a style=\"font-size: 15px;\" href=\"\/de\/verweise\/\"><sup>1-5<\/sup><\/a><\/li>\n<\/ul>    <\/div>\n<\/div>\n<!-- \/module text -->        <\/div>\n                    <\/div>\n                <div  data-lazy=\"1\" class=\"module_subrow themify_builder_sub_row tf_w col_align_top tb_col_count_3 tb_5ih5585\">\n                <div  data-lazy=\"1\" class=\"module_column sub_column col4-1 tb_xb5f586 first\">\n                            <\/div>\n                    <div  data-lazy=\"1\" class=\"module_column sub_column col4-2 tb_8h3x410\">\n                    <!-- module text -->\n<div  class=\"module module-text tb_yney128   \" data-lazy=\"1\">\n        <div  class=\"tb_text_wrap\">\n        <h3 class=\"p1\" style=\"text-align: center;\">\u00dcbereinstimmende klinische Ergebnisse in vier randomisierten kontrollierten Studien<\/h3>    <\/div>\n<\/div>\n<!-- \/module text --><!-- module text -->\n<div  class=\"module module-text tb_bm2b840    hide-tablet hide-mobile\" data-lazy=\"1\">\n        <div  class=\"tb_text_wrap\">\n        \n<table id=\"tablepress-8\" class=\"tablepress tablepress-id-8 studies tbody-has-connected-cells\">\n<tbody class=\"row-striping\">\n<tr class=\"row-1\">\n\t<td rowspan=\"2\" class=\"column-1\">RCT<\/td><td rowspan=\"2\" class=\"column-2\">Design<\/td><td rowspan=\"2\" class=\"column-3\">Patientenzahl und Follow-up Phase<\/td><td rowspan=\"2\" class=\"column-4\">Behandlungserfolg (TLVR%)<\/td><td colspan=\"3\" class=\"column-5\">Unterschied EBV vs Kontrollgruppe (ITT)<\/td>\n<\/tr>\n<tr class=\"row-2\">\n\t<td class=\"column-5\">Lungen Funktion<br \/>\n(fev<sub>1<\/sub>%)<br \/>\nMCID = 10%-15%<\/td><td class=\"column-6\">K\u00f6rperliche Leistungsf\u00e4higkeit<br \/>\n(6mwd)<br \/>\nMCID = 26 m<\/td><td class=\"column-7\">Lebensqualit\u00e4t<br \/>\n(sgrq)<br \/>\nMCID = -4 pts<\/td>\n<\/tr>\n<tr class=\"row-3\">\n\t<td class=\"column-1\">LIBERATE<a href=\"https:\/\/pulmonx.com\/references\/\" style=\"font-size: 15px;\"><sup>1<\/sup><\/a><\/td><td class=\"column-2\">2:1 Randomisierung<br \/>\n<b>Nur heterogen<\/b><br \/>\nMultizentrisch<\/td><td class=\"column-3\">n=190<br \/>\n12 Monate<\/td><td class=\"column-4\"><b>84%<\/b><\/td><td class=\"column-5\"><b>18.0%<\/b><br \/>\np<0.001<\/td><td class=\"column-6\"><b>39 m<\/b><br \/>\np=0.002<\/td><td class=\"column-7\"><b>-7.1 Punkte<\/b><br \/>\np=0.004<\/td>\n<\/tr>\n<tr class=\"row-4\">\n\t<td class=\"column-1\">TRANSFORM<a href=\"https:\/\/pulmonx.com\/references\/\" style=\"font-size: 15px;\"><sup>2<\/sup><\/a><\/td><td class=\"column-2\">2:1 Randomisierung<br \/>\n<b>Nur heterogen<\/b><br \/>\nMultizentrisch<\/td><td class=\"column-3\">n=97<br \/>\n6 Monate<\/td><td class=\"column-4\"><b>90%<\/b><\/td><td class=\"column-5\">29.3%<br \/>\np<0.001<\/td><td class=\"column-6\">79 m<br \/>\np<0.001<\/td><td class=\"column-7\">-6.5 Punkte<br \/>\np=0.031<\/td>\n<\/tr>\n<tr class=\"row-5\">\n\t<td class=\"column-1\">IMPACT<a href=\"https:\/\/pulmonx.com\/references\/\" style=\"font-size: 15px;\"><sup>3<\/sup><\/a><\/td><td class=\"column-2\">1:1 Randomisierung<br \/>\n<b>Nur homogen<\/b><br \/>\nMultizentrisch<\/td><td class=\"column-3\">n=93<br \/>\n6 Monate<\/td><td class=\"column-4\"><b>89%<\/b><\/td><td class=\"column-5\">16.3%<br \/>\np<0.001<\/td><td class=\"column-6\">28 m<br \/>\np=0.016<\/td><td class=\"column-7\">-7.5 Punkte<br \/>\np<0.001<\/td>\n<\/tr>\n<tr class=\"row-6\">\n\t<td class=\"column-1\">STELVIO<a href=\"https:\/\/pulmonx.com\/references\/\" style=\"font-size: 15px;\"><sup>4,5<\/sup><\/a><\/td><td class=\"column-2\">1:1 Randomisierung<br \/>\n<b>Heterogen und Homogen<\/b><br \/>\nMonozentrisch<\/td><td class=\"column-3\">n=68<br \/>\n6 Monate<\/td><td class=\"column-4\"><b>88%<\/b><\/td><td class=\"column-5\">17.8%<br \/>\np=0.001<\/td><td class=\"column-6\">74 m<br \/>\np<0.001<\/td><td class=\"column-7\">-14.7 Punkte*<br \/>\np<0.001<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n<h6 class=\"p1\">*Abgeschlossene F\u00e4lle, alle anderen Werte enstammen dem ITT-Kollektiv.<\/h6>\n<h6 class=\"p1\">M\u00f6gliche Komplikationen der Behandlung mit einem Endobronchialventil sind u.a. 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href=\"\/de\/verweise\/\"><sup>1<\/sup><\/a><\/h3>\n<blockquote>\n<p>Die Vorteile sind mit denen bei LVRS (Operation zur Reduktion des Lungenvolumens) vergleichbar, jedoch mit einer Verringerung der Morbidit\u00e4t nach dem Verfahren.\u201c<\/p>\n<\/blockquote>\n<ul>\n<li>Multizentrische, multinationale, randomisierte kontrollierte Studie<\/li>\n<li>Ergebnisse \u00fcber bis zu 12 Monate<\/li>\n<li>Heterogenes Emphysem mit geringer bis keiner Kollateralventilation<\/li>\n<li>Klinisch bedeutsamer und statistisch signifikanter Nutzen gegen\u00fcber der aktuellen Standardbehandlung in der Medizin<\/li>\n<li>Verbesserung bei:\n<ul>\n<li>Lungenfunktion<\/li>\n<li>Belastungstoleranz<\/li>\n<li>Dyspnoe<\/li>\n<li>Lebensqualit\u00e4t<\/li>\n<\/ul>\n<\/li>\n<\/ul>    <\/div>\n<\/div>\n<!-- \/module text --><!-- module buttons -->\n<div  class=\"module module-buttons tb_0bkp315 buttons-horizontal solid  large squared\" data-lazy=\"1\">\n        <div class=\"module-buttons-item tf_in_flx\">\n      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href=\"\/de\/verweise\/\"><sup>2<\/sup><\/a><\/h3>\n<blockquote>\n<p>Die Vorteile entsprechen denen bei der (operativen Lungenvolumenreduktion) LVRS, und die konsistenten Studienergebnisse, die potenzielle Verminderung der Morbidit\u00e4t nach dem Verfahren sowie die Reversibilit\u00e4t des Verfahrens positionieren die Zephyr-Behandlung als tragf\u00e4hige Option bei Patienten, die nach maximaler medikament\u00f6ser Therapie noch symptomatisch bleiben.\u201c<\/p>\n<\/blockquote>\n<ul>\n<li>Multizentrische, multinationale, randomisierte kontrollierte Studie<\/li>\n<li>Heterogenes Emphysem mit geringer oder keiner Kollateralventilation<\/li>\n<li>Klinisch bedeutsamer und statistisch signifikanter Nutzen gegen\u00fcber der aktuellen Standardbehandlung in der Medizin<\/li>\n<li>Verbesserung bei:\n<ul>\n<li>Lungenfunktion<\/li>\n<li>Belastungstoleranz<\/li>\n<li>Dyspnoe<\/li>\n<li>Lebensqualit\u00e4t<\/li>\n<\/ul>\n<\/li>\n<\/ul>    <\/div>\n<\/div>\n<!-- \/module text --><!-- module 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6 Monaten<\/h4>\n<p style=\"text-align: center;\"><!DOCTYPE html>\r\n<html>\r\n\t<head>\r\n\t\t<title>Clinical Study Page - German: IMPACT - FEV1 - Percent Change - Gray Background | amCharts<\/title>\r\n\t\t<meta name=\"description\" content=\"chart created using amCharts live editor\" \/>\r\n\t\t\r\n\t\t<!-- amCharts javascript sources -->\r\n\t\t<script type=\"text\/javascript\" src=\"https:\/\/www.amcharts.com\/lib\/3\/amcharts.js\"><\/script>\r\n\t\t<script type=\"text\/javascript\" src=\"https:\/\/cdn.amcharts.com\/lib\/3\/serial.js\"><\/script>\r\n\t\t<script type=\"text\/javascript\" src=\"https:\/\/www.amcharts.com\/lib\/3\/themes\/light.js\"><\/script>\r\n\t\t\r\n\r\n\t\t<!-- amCharts javascript code -->\r\n\t\t<script type=\"text\/javascript\">\r\n\t\t\tAmCharts.makeChart(\"german-IMPACT-fev1-percent-change\",\r\n\t\t\t\t{\r\n              \"hideCredits\": \"true\",\r\n\t\t\t\t\t\"type\": \"serial\",\r\n\t\t\t\t\t\"categoryField\": 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Critical Care Medicine<a style=\"font-size: 15px;\" href=\"\/de\/verweise\/\"><sup>3<\/sup><\/a><\/h3>\n<blockquote>\n<p>Die EBV-Behandlung f\u00fchrt bei ausgew\u00e4hlten Patienten mit homogenem Lungenemphysem ohne Kollateralventilation zu einem klinisch bedeutsamen Nutzen im Hinblick auf verbesserte Lungenfunktion, Belastungstoleranz und Lebensqualit\u00e4t. Angesichts der sehr begrenzten verf\u00fcgbaren Behandlungsoptionen f\u00fcr diese Patientenpopulation sollte die EBV-Therapie bei diesen Patienten in Erw\u00e4gung gezogen werden.\u201c<\/p>\n<\/blockquote>\n<ul>\n<li>Prospektive randomisierte kontrollierte Studie<\/li>\n<li>Homogenes Emphysem mit geringer oder keiner Kollateralventilation<\/li>\n<li>Klinisch bedeutsamer Nutzen in Bezug auf:\n<ul>\n<li>Lungenfunktion<\/li>\n<li>Belastungstoleranz<\/li>\n<li>Lebensqualit\u00e4t<\/li>\n<\/ul>\n<\/li>\n<\/ul>    <\/div>\n<\/div>\n<!-- \/module text -->        <div  data-lazy=\"1\" class=\"module_subrow themify_builder_sub_row tf_w col_align_top tb_col_count_2 tb_grxg107\">\n                <div  data-lazy=\"1\" class=\"module_column sub_column tb_glod109 first\">\n                    <!-- module buttons -->\n<div  class=\"module module-buttons tb_t4gf455 buttons-horizontal solid  large squared\" data-lazy=\"1\">\n        <div class=\"module-buttons-item tf_in_flx\">\n                     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    <\/div>\n                <\/div>\n                        <\/div>\n        <\/div>\n                        <div  data-css_id=\"ixzy593\" data-lazy=\"1\" class=\"module_row themify_builder_row fullwidth tb_ixzy593 tf_w\">\n                        <div class=\"row_inner col_align_top tb_col_count_2 tf_box tf_rel\">\n                        <div  data-lazy=\"1\" class=\"module_column tb-column col4-2 tb_8n37594 first\">\n                    <!-- module text -->\n<div  class=\"module module-text tb_bo87302   \" data-lazy=\"1\">\n        <div  class=\"tb_text_wrap\">\n        <h3>Ver\u00f6ffentlicht in The New England Journal of Medicine<a style=\"font-size: 15px;\" href=\"\/de\/verweise\/\"><sup>4<\/sup><\/a><\/h3>\n<blockquote>\n<p>Die Endobronchialventil-Behandlung zeigte bei Patienten mit Emphysem und nachgewiesener fehlender interlob\u00e4rer kollateraler Ventilation einen messbaren klinischen Nutzen bei signifikant verbesserter Lungenfunktion, Belastungsf\u00e4higkeit und Lebensqualit\u00e4t im Vergleich zur \u00fcblichen Behandlung.\u201c<\/p>\n<\/blockquote>\n<ul>\n<li>Prospektive randomisierte kontrollierte Studie<\/li>\n<li>Erste randomisierte Studie zur Verwendung von Chartis<sup>\u00ae<\/sup> zur Vorauswahl von Kandidaten<\/li>\n<li>Emphysem mit geringer oder keiner Kollateralventilation<\/li>\n<li>Statistisch und klinisch gr\u00f6\u00dfere Verbesserungen als die Kontrollgruppe in Bezug auf:\n<ul>\n<li>Lungenfunktion (Einsekundenkapazit\u00e4t FEV<sub>1<\/sub> und FVC)<\/li>\n<li>Belastungsf\u00e4higkeit<\/li>\n<li>Lebensqualit\u00e4t<\/li>\n<\/ul>\n<\/li>\n<li>Einj\u00e4hrige Nachbeobachtung ver\u00f6ffentlicht in The American Journal of Respiratory and Critical Care Medicine<a href=\"\/de\/verweise\/\"><sup>5<\/sup><\/a><\/li>\n<\/ul>\n<p><a name=\"guidelines\"><\/a><\/p>    <\/div>\n<\/div>\n<!-- \/module text --><!-- module buttons -->\n<div  class=\"module module-buttons tb_a0u1552 buttons-horizontal solid  large squared\" data-lazy=\"1\">\n  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[\r\n\t\t\t\t\t\t{\r\n\t\t\t\t\t\t\t\"id\": \"ValueAxis-1\",\r\n\t\t\t\t\t\t\t\"maximum\": 31,\r\n\t\t\t\t\t\t\t\"minimum\": -10,\r\n\t\t\t\t\t\t\t\"gridCount\": 9,\r\n\t\t\t\t\t\t\t\"title\": \"Prozentuale (%)\"\r\n\t\t\t\t\t\t}\r\n\t\t\t\t\t],\r\n\t\t\t\t\t\"allLabels\": [\r\n\t\t\t\t\t\t{\r\n\t\t\t\t\t\t\t\"id\": \"p = 0,001\",\r\n\t\t\t\t\t\t\t\"text\": \"(p = 0,001)\",\r\n\t\t\t\t\t\t\t\"x\": \"70%\",\r\n\t\t\t\t\t\t\t\"y\": \"25%\"\r\n\t\t\t\t\t\t},\r\n\t\t\t\t\t\t{\r\n\t\t\t\t\t\t\t\"bold\": true,\r\n\t\t\t\t\t\t\t\"id\": \"=17.8%\",\r\n\t\t\t\t\t\t\t\"text\": \"\u0394 = 17,8%\",\r\n\t\t\t\t\t\t\t\"x\": \"70%\",\r\n\t\t\t\t\t\t\t\"y\": 54\r\n\t\t\t\t\t\t}\r\n\t\t\t\t\t],\r\n\t\t\t\t\t\"balloon\": {\r\n\t\t\t\t\t\t\"borderThickness\": 1\r\n\t\t\t\t\t},\r\n\t\t\t\t\t\"titles\": [],\r\n\t\t\t\t\t\"dataProvider\": [\r\n\t\t\t\t\t\t{\r\n\t\t\t\t\t\t\t\"category\": \"Zephyr-Ventil<br>(n=34)\",\r\n\t\t\t\t\t\t\t\"column-2\": \"11.1\",\r\n\t\t\t\t\t\t\t\"column-3\": \"30.7\",\r\n\t\t\t\t\t\t\t\"Color\": \"#4f2d7f\",\r\n\t\t\t\t\t\t\t\"Column Height\": \"20.9\"\r\n\t\t\t\t\t\t},\r\n\t\t\t\t\t\t{\r\n\t\t\t\t\t\t\t\"category\": \"Kontrolle<br>(n=34)\",\r\n\t\t\t\t\t\t\t\"column-2\": \"-0.4\",\r\n\t\t\t\t\t\t\t\"column-3\": \"6.6\",\r\n\t\t\t\t\t\t\t\"Color\": \"#3095b4\",\r\n\t\t\t\t\t\t\t\"Column Height\": \"3.1\"\r\n\t\t\t\t\t\t}\r\n\t\t\t\t\t]\r\n\t\t\t\t}\r\n\t\t\t);\r\n\t\t<\/script>\r\n\t<\/head>\r\n\t<body>\r\n\t\t<div id=\"german-STELVIO-FEV1 Percent-Change-from-Baseline-to-6-Months\" style=\"width: 100%; height: 400px; background-color: #FFFFFF;\" ><\/div>\r\n\t<\/body>\r\n<\/html><\/p>\n    <\/div>\n<\/div>\n<!-- \/module text -->        <\/div>\n                        <\/div>\n        <\/div>\n                        <div  data-css_id=\"f75g984\" data-lazy=\"1\" class=\"module_row themify_builder_row fullwidth tb_f75g984 tf_w\">\n            <span class=\"tb_row_frame_wrap tf_overflow tf_abs\" data-lazy=\"1\"><span class=\"tb_row_frame tb_row_frame_top  tf_abs tf_hide tf_overflow tf_w\"><\/span><\/span>            <div class=\"row_inner col_align_top tb_col_count_3 tf_box tf_rel\">\n                        <div  data-lazy=\"1\" class=\"module_column tb-column col4-1 tb_fell986 first\">\n                    <!-- module divider -->\n<div  class=\"module tf_mw module-divider tb_jlv3987 solid   \" style=\"border-width: 0px;border-color: #ffffff;margin-top: 30px;margin-bottom: 8px;\" data-lazy=\"1\">\n    <\/div>\n<!-- \/module divider -->\n        <\/div>\n                    <div  data-lazy=\"1\" class=\"module_column tb-column col4-2 tb_nubv417\">\n                    <!-- module text -->\n<div  class=\"module module-text tb_y1ww987   \" data-lazy=\"1\">\n        <div  class=\"tb_text_wrap\">\n        <h2 style=\"text-align: center;\"><strong>In internationalen Leitlinien wird die Behandlung mit einem Endobronchialventil als Option f\u00fcr Emphysem-Patienten genannt<\/strong><\/h2>\n<p style=\"text-align: center;\">Mehrere unabh\u00e4ngige Netzwerke sind zu dem Schluss gekommen, dass bei richtiger Patientenauswahl das Zephyr-Ventil-Verfahren bei der Behandlung von schwerem Emphysem in Betracht gezogen werden sollte.<\/p>    <\/div>\n<\/div>\n<!-- \/module text -->        <div  data-lazy=\"1\" class=\"module_subrow themify_builder_sub_row tf_w col_align_top tb_col_count_2 tb_popy445\">\n                <div  data-lazy=\"1\" class=\"module_column sub_column tb_ampw447 first\">\n                    <!-- module text -->\n<div  class=\"module module-text tb_m2dy511   \" data-lazy=\"1\">\n        <div  class=\"tb_text_wrap\">\n        <p>Der Behandlung mit Endobronchialventilen wurde von der Global Initiative for Chronic Obstructive Lung Disease (GOLD) die Evidenzstufe \u201eA\u201c zuerkannt.<a href=\"\/de\/verweise\/\"><sup>10<\/sup><\/a><\/p>    <\/div>\n<\/div>\n<!-- \/module text -->        <\/div>\n                    <div  data-lazy=\"1\" class=\"module_column sub_column tb_3io2448 last\">\n                    <!-- module text -->\n<div  class=\"module module-text tb_fsh2597   \" data-lazy=\"1\">\n        <div  class=\"tb_text_wrap\">\n        <p>Das National Institute for Health and Care Excellence (NICE) im Vereinigten K\u00f6nigreich betrachtet diese Behandlung als Teil der Standardma\u00dfnahmen bei COPD und empfiehlt, alle infrage kommenden Patienten hinsichtlich ihrer Eignung zu bewerten.<a href=\"\/de\/verweise\/\"><sup>11,34<\/sup><\/a><\/p>    <\/div>\n<\/div>\n<!-- \/module text -->        <\/div>\n                    <\/div>\n                <div  data-lazy=\"1\" class=\"module_subrow themify_builder_sub_row tf_w col_align_top tb_col_count_2 tb_5ezp562\">\n                <div  data-lazy=\"1\" class=\"module_column sub_column col4-2 tb_6pmq563 first\">\n                    <!-- module image -->\n<div  class=\"module module-image tb_ppn5483 image-center   tf_mw\" data-lazy=\"1\">\n        <div class=\"image-wrap tf_rel tf_mw\">\n            <a href=\"https:\/\/goldcopd.org\/gold-reports\/\" rel=\"noopener\" target=\"_blank\">\n                   <img decoding=\"async\" src=\"https:\/\/pulmonx.com\/wp-content\/uploads\/2019\/09\/GOLD-Guidelines-Zephyr-Valve-350x168.png\" width=\"350\" height=\"168\" class=\"wp-post-image wp-image-80543\" title=\"GOLD-Guidelines-Zephyr-Valve\" alt=\"GOLD-Guidelines-Zephyr-Valve\" srcset=\"https:\/\/pulmonx.com\/wp-content\/uploads\/2019\/09\/GOLD-Guidelines-Zephyr-Valve-350x168.png 350w, https:\/\/pulmonx.com\/wp-content\/uploads\/2019\/09\/GOLD-Guidelines-Zephyr-Valve-300x145.png 300w, https:\/\/pulmonx.com\/wp-content\/uploads\/2019\/09\/GOLD-Guidelines-Zephyr-Valve-768x371.png 768w, https:\/\/pulmonx.com\/wp-content\/uploads\/2019\/09\/GOLD-Guidelines-Zephyr-Valve.png 800w\" sizes=\"(max-width: 350px) 100vw, 350px\" \/>        <\/a>\n    \n        <\/div>\n    <!-- \/image-wrap -->\n    \n        <\/div>\n<!-- \/module image -->        <\/div>\n                    <div  data-lazy=\"1\" class=\"module_column sub_column col4-2 tb_uds4563 last\">\n                    <!-- module image -->\n<div  class=\"module module-image tb_x8n6579 image-center   tf_mw\" data-lazy=\"1\">\n        <div class=\"image-wrap tf_rel tf_mw\">\n            <a href=\"https:\/\/www.nice.org.uk\/guidance\/ipg600\" rel=\"noopener\" target=\"_blank\">\n                   <img decoding=\"async\" src=\"https:\/\/pulmonx.com\/wp-content\/uploads\/2019\/09\/NICE-Guidelines-Zephyr-Valve-350x168.png\" width=\"350\" height=\"168\" class=\"wp-post-image wp-image-80549\" title=\"NICE-Guidelines-Zephyr-Valve\" alt=\"NICE-Guidelines-Zephyr-Valve\" srcset=\"https:\/\/pulmonx.com\/wp-content\/uploads\/2019\/09\/NICE-Guidelines-Zephyr-Valve-350x168.png 350w, https:\/\/pulmonx.com\/wp-content\/uploads\/2019\/09\/NICE-Guidelines-Zephyr-Valve-300x145.png 300w, https:\/\/pulmonx.com\/wp-content\/uploads\/2019\/09\/NICE-Guidelines-Zephyr-Valve-768x371.png 768w, https:\/\/pulmonx.com\/wp-content\/uploads\/2019\/09\/NICE-Guidelines-Zephyr-Valve.png 800w\" sizes=\"(max-width: 350px) 100vw, 350px\" \/>        <\/a>\n    \n        <\/div>\n    <!-- \/image-wrap -->\n    \n        <\/div>\n<!-- \/module image -->        <\/div>\n                    <\/div>\n                <div  data-lazy=\"1\" class=\"module_subrow themify_builder_sub_row tf_w col_align_top tb_col_count_2 tb_fk2u873\">\n                <div  data-lazy=\"1\" class=\"module_column sub_column col4-2 tb_8lpz874 first\">\n                    <!-- module image -->\n<div  class=\"module module-image tb_77oz13 image-center   tf_mw\" data-lazy=\"1\">\n        <div class=\"image-wrap tf_rel tf_mw\">\n            <a href=\"https:\/\/www.awmf.org\/leitlinien\/detail\/ll\/020-006.html\" rel=\"noopener\" target=\"_blank\">\n                   <img decoding=\"async\" src=\"https:\/\/pulmonx.com\/wp-content\/uploads\/2020\/04\/DEUTSCHE-GESELLSCHAFT-FUR-PNEUMOLOGIE-UND-BEATMUNGSMEDIZIN-350x175.png\" width=\"350\" height=\"175\" class=\"wp-post-image wp-image-74978\" title=\"DEUTSCHE-GESELLSCHAFT-FUR-PNEUMOLOGIE-UND-BEATMUNGSMEDIZIN\" alt=\"DEUTSCHE-GESELLSCHAFT-FUR-PNEUMOLOGIE-UND-BEATMUNGSMEDIZIN\" srcset=\"https:\/\/pulmonx.com\/wp-content\/uploads\/2020\/04\/DEUTSCHE-GESELLSCHAFT-FUR-PNEUMOLOGIE-UND-BEATMUNGSMEDIZIN-350x175.png 350w, https:\/\/pulmonx.com\/wp-content\/uploads\/2020\/04\/DEUTSCHE-GESELLSCHAFT-FUR-PNEUMOLOGIE-UND-BEATMUNGSMEDIZIN-300x150.png 300w, https:\/\/pulmonx.com\/wp-content\/uploads\/2020\/04\/DEUTSCHE-GESELLSCHAFT-FUR-PNEUMOLOGIE-UND-BEATMUNGSMEDIZIN-768x384.png 768w, https:\/\/pulmonx.com\/wp-content\/uploads\/2020\/04\/DEUTSCHE-GESELLSCHAFT-FUR-PNEUMOLOGIE-UND-BEATMUNGSMEDIZIN.png 800w\" sizes=\"(max-width: 350px) 100vw, 350px\" \/>        <\/a>\n    \n        <\/div>\n    <!-- \/image-wrap -->\n    \n        <\/div>\n<!-- \/module image -->        <\/div>\n                    <div  data-lazy=\"1\" class=\"module_column sub_column col4-2 tb_99a8875 last\">\n                    <!-- module image -->\n<div  class=\"module module-image tb_a0d3875 image-center   tf_mw\" data-lazy=\"1\">\n        <div class=\"image-wrap tf_rel tf_mw\">\n            <a href=\"https:\/\/www.zorginstituutnederland.nl\/publicaties\/standpunten\/2017\/09\/14\/standpunt-endobronchiale-longvolumereductie-middels-eenrichtingskleppen-bij-ernstig-longemfyseem\" rel=\"noopener\" target=\"_blank\">\n                   <img decoding=\"async\" src=\"https:\/\/pulmonx.com\/wp-content\/uploads\/2020\/04\/ZORGINSTITUUT-NEDERLAND-350x175.png\" width=\"350\" height=\"175\" class=\"wp-post-image wp-image-74983\" title=\"ZORGINSTITUUT-NEDERLAND\" alt=\"ZORGINSTITUUT-NEDERLAND\" srcset=\"https:\/\/pulmonx.com\/wp-content\/uploads\/2020\/04\/ZORGINSTITUUT-NEDERLAND-350x175.png 350w, https:\/\/pulmonx.com\/wp-content\/uploads\/2020\/04\/ZORGINSTITUUT-NEDERLAND-300x150.png 300w, https:\/\/pulmonx.com\/wp-content\/uploads\/2020\/04\/ZORGINSTITUUT-NEDERLAND-768x384.png 768w, https:\/\/pulmonx.com\/wp-content\/uploads\/2020\/04\/ZORGINSTITUUT-NEDERLAND.png 800w\" sizes=\"(max-width: 350px) 100vw, 350px\" \/>        <\/a>\n    \n        <\/div>\n    <!-- \/image-wrap -->\n    \n        <\/div>\n<!-- \/module image -->        <\/div>\n                    <\/div>\n        <!-- module text -->\n<div  class=\"module module-text tb_vs4i308   \" data-lazy=\"1\">\n        <div  class=\"tb_text_wrap\">\n        <h2 style=\"text-align: center;\"><strong>Lungenvolumenreduktion ist Teil des Behandlungsalgorithmus bei chronischer COPD in Deutschland<\/strong><\/h2>\n<p style=\"text-align: center;\">Disease Management Programme (DMP) tragen in Deutschland dazu bei, Patienten mit chronischer Erkrankung interdisziplin\u00e4r nach aktuellem Stand der Wissenschaft zu behandeln. <br><br>Die Lungenvolumenreduktion, z.\u00a0B. mit dem Zephyr\u00ae Endobronchialventil, ist nun als Therapieoption bei Patienten mit schwerem Lungenemphysem empfohlen.<\/p>    <\/div>\n<\/div>\n<!-- \/module text -->        <div  data-lazy=\"1\" class=\"module_subrow themify_builder_sub_row tf_w col_align_top tb_col_count_2 tb_grnz583\">\n                <div  data-lazy=\"1\" class=\"module_column sub_column col4-2 tb_qyhz583 first\">\n                    <!-- module image -->\n<div  class=\"module module-image tb_pw6q583 image-center   tf_mw\" data-lazy=\"1\">\n        <div class=\"image-wrap tf_rel tf_mw\">\n            <a href=\"https:\/\/www.awmf.org\/leitlinien\/detail\/ll\/020-006.html\" rel=\"noopener\" target=\"_blank\">\n                   <img decoding=\"async\" src=\"https:\/\/pulmonx.com\/wp-content\/uploads\/2023\/03\/gb-logo-1024x416-350x142.png\" width=\"350\" height=\"142\" class=\"wp-post-image wp-image-82764\" title=\"gb-logo\" alt=\"gb-logo\" srcset=\"https:\/\/pulmonx.com\/wp-content\/uploads\/2023\/03\/gb-logo-1024x416-350x142.png 350w, https:\/\/pulmonx.com\/wp-content\/uploads\/2023\/03\/gb-logo-300x122.png 300w, https:\/\/pulmonx.com\/wp-content\/uploads\/2023\/03\/gb-logo-1024x416.png 1024w, https:\/\/pulmonx.com\/wp-content\/uploads\/2023\/03\/gb-logo-768x312.png 768w, https:\/\/pulmonx.com\/wp-content\/uploads\/2023\/03\/gb-logo-1536x625.png 1536w, https:\/\/pulmonx.com\/wp-content\/uploads\/2023\/03\/gb-logo-2048x833.png 2048w\" sizes=\"(max-width: 350px) 100vw, 350px\" \/>        <\/a>\n    \n        <\/div>\n    <!-- \/image-wrap -->\n    \n        <\/div>\n<!-- \/module image -->        <\/div>\n                    <div  data-lazy=\"1\" class=\"module_column sub_column col4-2 tb_0hue583 last\">\n                    <!-- module image -->\n<div  class=\"module module-image tb_yrq3583 image-center   tf_mw\" data-lazy=\"1\">\n        <div class=\"image-wrap tf_rel tf_mw\">\n            <a href=\"https:\/\/www.zorginstituutnederland.nl\/publicaties\/standpunten\/2017\/09\/14\/standpunt-endobronchiale-longvolumereductie-middels-eenrichtingskleppen-bij-ernstig-longemfyseem\" rel=\"noopener\" target=\"_blank\">\n                   <img decoding=\"async\" src=\"https:\/\/pulmonx.com\/wp-content\/uploads\/2023\/03\/kb-logo-1-1024x416-350x142.png\" width=\"350\" height=\"142\" class=\"wp-post-image wp-image-82770\" title=\"kb-logo\" alt=\"kb-logo\" srcset=\"https:\/\/pulmonx.com\/wp-content\/uploads\/2023\/03\/kb-logo-1-1024x416-350x142.png 350w, https:\/\/pulmonx.com\/wp-content\/uploads\/2023\/03\/kb-logo-1-300x122.png 300w, https:\/\/pulmonx.com\/wp-content\/uploads\/2023\/03\/kb-logo-1-1024x416.png 1024w, https:\/\/pulmonx.com\/wp-content\/uploads\/2023\/03\/kb-logo-1-768x312.png 768w, https:\/\/pulmonx.com\/wp-content\/uploads\/2023\/03\/kb-logo-1-1536x625.png 1536w, https:\/\/pulmonx.com\/wp-content\/uploads\/2023\/03\/kb-logo-1-2048x833.png 2048w\" sizes=\"(max-width: 350px) 100vw, 350px\" \/>        <\/a>\n    \n        <\/div>\n    <!-- \/image-wrap -->\n    \n        <\/div>\n<!-- \/module image -->        <\/div>\n                    <\/div>\n                <\/div>\n                    <div  data-lazy=\"1\" class=\"module_column tb-column col4-1 tb_jz4c419 last\">\n                            <\/div>\n                        <\/div>\n        <\/div>\n                        <div  data-css_id=\"2sl4723\" data-lazy=\"1\" class=\"module_row themify_builder_row fullwidth tb_2sl4723 tf_w\">\n                        <div class=\"row_inner col_align_top tb_col_count_2 tf_box tf_rel\">\n                        <div  data-lazy=\"1\" class=\"module_column tb-column col4-3 tb_t9vz725 first\">\n                    <!-- module text -->\n<div  class=\"module module-text tb_7vr3791   \" data-lazy=\"1\">\n        <div  class=\"tb_text_wrap\">\n        <h2 style=\"text-align: center;\">Von den Patienten bevorzugte Behandlung<\/h2>    <\/div>\n<\/div>\n<!-- \/module text -->        <div  data-lazy=\"1\" class=\"module_subrow themify_builder_sub_row tf_w col_align_top tb_col_count_2 tb_q57d322\">\n                <div  data-lazy=\"1\" class=\"module_column sub_column col4-2 tb_z49l323 first\">\n                    <!-- module image -->\n<div  class=\"module module-image tb_18eb867 image-top   tf_mw\" data-lazy=\"1\">\n        <div class=\"image-wrap tf_rel tf_mw\">\n            <a href=\"\/references\">\n                   <img decoding=\"async\" width=\"800\" height=\"800\" src=\"https:\/\/pulmonx.com\/wp-content\/uploads\/2020\/05\/Infographic-3-in-4-Translation-German.png\" class=\"wp-post-image wp-image-76382\" title=\"Infographic-3-in-4-Translation-German\" alt=\"Infographic-3-in-4-Translation-German\" srcset=\"https:\/\/pulmonx.com\/wp-content\/uploads\/2020\/05\/Infographic-3-in-4-Translation-German.png 800w, https:\/\/pulmonx.com\/wp-content\/uploads\/2020\/05\/Infographic-3-in-4-Translation-German-300x300.png 300w, https:\/\/pulmonx.com\/wp-content\/uploads\/2020\/05\/Infographic-3-in-4-Translation-German-150x150.png 150w, https:\/\/pulmonx.com\/wp-content\/uploads\/2020\/05\/Infographic-3-in-4-Translation-German-768x768.png 768w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>        <\/a>\n    \n        <\/div>\n    <!-- \/image-wrap -->\n    \n        <\/div>\n<!-- \/module image -->        <\/div>\n                    <div  data-lazy=\"1\" class=\"module_column sub_column col4-2 tb_5f58323 last\">\n                    <!-- module text -->\n<div  class=\"module module-text tb_7bgq159   \" data-lazy=\"1\">\n        <div  class=\"tb_text_wrap\">\n        <p>294 Patienten mit schwerem Lungenemphysem wurden in einer ausf\u00fchrlichen Erhebung gefragt, wie sie potenzielle Risiken und Vorteile bewerten. Die Untersuchung ergab, dass Patienten mit schwerem Emphysem den Zugang zu einer interventionellen Behandlung vorziehen, die \u00fcber die derzeitige medizinische Behandlung hinaus Vorteile bietet, trotz der damit verbundenen Risiken.<a style=\"font-size: 15px;\" href=\"\/de\/verweise\/\"><sup>8<\/sup><\/a><\/p>    <\/div>\n<\/div>\n<!-- \/module text --><!-- module buttons -->\n<div  class=\"module module-buttons tb_o011353 buttons-horizontal solid  large squared\" data-lazy=\"1\">\n        <div class=\"module-buttons-item tf_in_flx\">\n                        <a href=\"\/de\/patientengeschichten\" class=\"ui builder_button tf_in_flx tb_default_color\" >\n                                                Mehr erfahren                                        <\/a>\n                <\/div>\n            <\/div>\n<!-- \/module buttons -->\n        <\/div>\n                    <\/div>\n                <\/div>\n                    <div  data-lazy=\"1\" class=\"module_column tb-column col4-1 tb_tjez666 last\">\n                            <\/div>\n                        <\/div>\n        <\/div>\n                        <div  data-lazy=\"1\" class=\"module_row themify_builder_row tb_s9q0400 tf_w\">\n                        <div class=\"row_inner col_align_top tb_col_count_1 tf_box tf_rel\">\n                        <div  data-lazy=\"1\" class=\"module_column tb-column col-full tb_78j0402 first\">\n                    <!-- module text -->\n<div  class=\"module module-text tb_heit532   \" data-lazy=\"1\">\n        <div  class=\"tb_text_wrap\">\n        <h2 style=\"text-align: center;\">M\u00f6chten Sie mehr wissen?<\/h2>    <\/div>\n<\/div>\n<!-- \/module text -->        <div  data-lazy=\"1\" class=\"module_subrow themify_builder_sub_row tf_w col_align_top tb_col_count_4 tb_g6on45\">\n                <div  data-lazy=\"1\" class=\"module_column sub_column col4-1 tb_0o4b46 first\">\n                            <\/div>\n                    <div  data-lazy=\"1\" class=\"module_column sub_column col4-1 tb_z1gj46\">\n                    <!-- module buttons -->\n<div  class=\"module module-buttons tb_vrsg75 buttons-horizontal solid  large squared\" data-lazy=\"1\">\n        <div class=\"module-buttons-item tf_in_flx\">\n                        <a href=\"\/de\/verweise\/\" class=\"ui builder_button tf_in_flx tb_default_color\" >\n                                                Vollst\u00e4ndige Bibliographie lesen                                        <\/a>\n                <\/div>\n            <\/div>\n<!-- \/module buttons -->\n        <\/div>\n                    <div  data-lazy=\"1\" class=\"module_column sub_column col4-1 tb_st2b47\">\n                    <!-- module buttons -->\n<div  class=\"module module-buttons tb_9558995 buttons-horizontal solid  large squared\" data-lazy=\"1\">\n        <div class=\"module-buttons-item tf_in_flx\">\n                        <a href=\"\/de\/download-klinische-studien\/\" class=\"ui builder_button tf_in_flx tb_default_color\" >\n                                                Download klinische Studien                                        <\/a>\n                <\/div>\n            <\/div>\n<!-- \/module buttons -->\n        <\/div>\n                    <div  data-lazy=\"1\" class=\"module_column sub_column col4-1 tb_5qfi47 last\">\n                            <\/div>\n                    <\/div>\n                <div  data-lazy=\"1\" class=\"module_subrow themify_builder_sub_row tf_w col_align_top tb_col_count_1 tb_mld6805\">\n                <div  data-lazy=\"1\" class=\"module_column sub_column col-full tb_153e807 first\">\n                    <!-- module text -->\n<div  class=\"module module-text tb_yk19651   \" data-lazy=\"1\">\n        <div  class=\"tb_text_wrap\">\n        <h6>*Intent-to-Treat<\/h6>    <\/div>\n<\/div>\n<!-- \/module text -->        <\/div>\n                    <\/div>\n                <\/div>\n                        <\/div>\n        <\/div>\n        <\/div>\n<!--\/themify_builder_content-->\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-82733","page","type-page","status-publish","hentry","has-post-title","has-post-date","has-post-category","has-post-tag","has-post-comment","has-post-author",""],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.1 - 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