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Publications and Case Studies

There are numerous scientific publications describing use of the Zephyr® Endobronchial Valve system and the Chartis® Pulmonary Assessment System. A selected bibliography of some of the more recent publications is grouped below by topic.

Zephyr EBV Treatment

  1. Sciurba F, et al. A Randomized Study of Endobronchial Valves for Advanced Emphysema. New England Journal of Medicine, 2010; 363:1233-1244.
  2. Hopkinson, N.S., Bronchoscopic lung volume reduction: indications, effects and prospects. Curr Opin Pulm Med, 2007. 13: p. 125-130.
  3. Polkey, M.I. and N.S. Hopkinson, Bronchoscopic lung volume reduction. Eur Respir Rev, 2006. 15(100): p. 99-103.
  4. Venuta, F., et al., Bronchoscopic procedures for emphysema treatment. European Journal of Cardio-thoracic Surgery, 2006. 29: p. 281-287.
  5. Wan, I.Y., et al., Bronchoscopic Lung Volume Reduction for End-Stage Emphysema: Report on the First 98 Patients. Chest, 2006. 129(3): p. 518-526.
  6. de Oliveira, H., et al., Transbronchoscopic Pulmonary Emphysema Treatment: 1-Month to 24-Month Endoscopic Follow-up. Chest, 2006. 130(1): p. 190-199.
  7. Venuta, F., et al., Bronchoscopic Lung-Volume Reduction With One-Way Valves in Patients With Heterogenous Emphysema. Ann Thorac Surg, 2005. 79(2): p. 411-417.
  8. Hopkinson, N.S., et al., Effect of Bronchoscopic Lung Volume Reduction on Dynamic Hyperinflation and Exercise in Emphysema. Am. J. Respir. Crit. Care Med., 2005. 171(5): p. 453-460.
  9. Snell, G., et al., The Potential for Bronchoscopic Lung Volume Reduction Using Bronchial Prostheses: A Pilot Study. Chest, 2003. 124(3): p. 1073-1080.

EBV Treatment of Giant Bullae

  1. Santini M, et al. Endobronchial treatment of giant emphysematous bullae with one-way valves: a new approach for surgically unfit patients. Eur J Cardiothorac Surg (2011), doi:10.1016/j.ejcts.2011.03.046
  2. Noppen, M., et al., Successful Treatment of a Giant Emphysematous Bulla by Bronchoscopic Placement of Endobronchial Valves. Chest, 2006. 130(5): p. 1563 1565.

EBV – Long-term follow-up and survival

  1. Kotecha, et.al. Long-Term Outcomes from Bronchoscopic Lung Volume Reduction using a bronchial prosthesis, Respirology 2011
  2. Hopkinson, N., et al. Atelectasis and Survival after Bronchoscopic Lung Volume Reduction for COPD. ERJ Express, published online October 14, 2010 (DOI: 10.1183/09031936.00100110)

Chartis System and Collateral Ventilation

  1. Gompelmann D, Eberhardt R, Michaud G, Ernst A, Herth FJF. Predicting Atelectasis by Assessment of Collateral Ventilation prior to Endobronchial Lung Volume Reduction: A Feasibility Study. Respiration (DOI:10.1159/000319441), Published Online: July 21, 2010.
  2. Mantri, S., et al., Measurement of Collateral Flow in the Lung with a Dedicated Endobronchial Catheter System. J Bonchol Intervent Pulmonol, 2009. 16(2): p.141-144.
  3. Aljuiri, N., and Freitag, L. Validation and pilot clinical study of a new bronchoscopic method to measure collateral ventilation before endobronchial lung volume reduction. J Appl Physiol 106: 774-783, 2009.
  4. Fessler, H. Collateral damage assessment for endobronchial lung volume reduction. J Appl Physiol 106: 755-756, 2009.
  5. Cetti, E.J., A.J. Moore, and D.M. Geddes, Collateral ventilation. Thorax, 2006. 61: p. 371-373.
  6. Salanitri, J., et al., 133 Xenon ventilation scintigraphy applied to bronchoscopic lung volume reduction techniques for emphysema: relevance of interlobar collaterals. Internal medicine Journal, 2005. 35: p. 97-103.

Air Leaks / Bronchopleural Fistula

  1. Travaline, JM, et al., Treatment of Persistent Pulmonary Air Leaks Using Endobronchial Valves. Chest, 2009. Pre-published online, April 6, 2009.
  2. Toma, TP, et al., Reduction of persistent air leak with endoscopic valve implants. Thorax, 2007. 62(9): 829-32.
  3. Anile, M., et al., Treatment of persistent air leakage with endobronchial one-way valves. The Journal of Thoracic and Cardiovascular Surgery, 2006. 132(3): p. 711-712.
  4. De Giacomo, T., et al., Successful treatment with one-way endobronchial valve of large air-leakage complicating narrow-bore enteral feeding tube malposition. Eur J Cardiothorac Surg, 2006. 30(5): p. 811-812.
  5. Fann, J.I., G.J. Berry, and T.A. Burdon, The use of endobronchial valve device to eliminate air leak. Respir Med. 2006;100(8):1402-6. Epub 2006 Jan 11.
  6. Feller-Kopman, D., et al., Use of a Removable Endobronchial Valve for the Treatment of Bronchopleural Fistula. Chest, 2006. 130(1): p. 273-275.
  7. Ferguson, J.S., K. Sprenger, and T. Van Natta, Closure of a Bronchopleural Fistula Using Bronchoscopic Placement of an Endobronchial Valve Designed for the Treatment of Emphysema. Chest, 2006. 129(2): p. 479-481.
  8. Mitchell, K., T. Boley, and S. Hazelrigg, Endobronchial Valves for Treatment of Bronchopleural Fistula. Ann Thorac Surg, 2006. 81(3): p. 1129-1131.
  9. Snell, G., et al., Occlusion of a Broncho-Cutaneous Fistula With Endobronchial One-Way Valves. Ann Thorac Surg, 2005. 80(5): p. 1930-1932.

Native Lung Hyperinflation in Transplant Patients

  1. Kemp, et.al. A Potential Role for endobronchial valves in patients with Lung Transplant, Journal of heart and Lung Transplantation, Vol 29, No. 11, November 2010
  2. Pato, et.al., Bronchoscopic Lung Volume Reduction in a Single-Lung Transplant Recipient with Natal Lung Hyperinflation: A Case Report, Transplantation Proceedings, 42, 1979-1981 (2010)
  3. Crespo, M.M., et al., Use of Endobronchial Valves for Native Lung Hyperinflation Associated with Respiratory Failure in a Single-Lung transplant Recipient for Emphysema. Chest, 2007. 131: p. 214-216.

Bridge-to-Transplantation

  1. Venuta, F., et.al. Bronchoscopic Lung Volume Reduction as a Bridge to lung transplantation in patients with chronic obstructive pulmonary disease, Eur J Cardiothoracic Surg (2010)

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